Evidence map›Paper›PMID 34657283›Full record

ArticleThe New phytologist2022

A phytobacterial TIR domain effector manipulates NAD

Samuel Eastman, Thomas Smith, Mark A Zaydman, Panya Kim, Samuel Martinez, Neha Damaraju, Aaron DiAntonio, Jeffrey Milbrandt, Thomas E Clemente, James R Alfano and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. International journal of molecular sciences · 2026
    Article
  4. Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026
    Review
  5. Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. TIR innovations in plant immunity.The New phytologist · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. TheProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Samuel EastmanDepartment of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Thomas SmithDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Mark A ZaydmanDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Panya KimThe Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID 0000-0002-0191-4264
Samuel MartinezSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Neha DamarajuDepartment of Biomedical Engineering, Washington University in St Louis, St Louis, MO, 63130, USA.
Aaron DiAntonioDepartment of Developmental Biology, Washington University School of Medicine, St Louis, MO, 63110, USA.ORCID 0000-0002-7262-0968
Jeffrey MilbrandtDepartment of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.ORCID 0000-0002-5477-7689
Thomas E ClementeDepartment of Agriculture and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.ORCID 0000-0003-3650-852X
James R AlfanoDepartment of Plant Pathology, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
Ming GuoDepartment of Agriculture and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.ORCID 0000-0001-5338-9353
University of Nebraska–Lincoln · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pseudomonas syringae DC3000 type III effector HopAM1 suppresses plant immunity and contains a Toll/interleukin-1 receptor (TIR) domain homologous to immunity-related TIR domains of plant nucleotide-binding leucine-rich repeat receptors that hydrolyze nicotinamide adenine dinucleotide (NAD

Indexed as

ArabidopsisArabidopsis ProteinsBacterial ProteinsNADPlant DiseasesPseudomonas syringaeReceptors, Interleukin-1VirulenceArabidopsis ProteinsBacterial ProteinsNADReceptors, Interleukin-1cADPR variantHopAM1NAD+NAD+ hydrolasePseudomonas syringaeTIR domainv2-cADPRv-cADPR

Identifiers

PMID34657283
PMCPMC9298051
OpenAlexW3206070115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.