Evidence map›Paper›PMID 34657271›Full record

SynthesisCerebellum (London, England)2022

The Contribution of Neuroimaging to the Understanding of Essential Tremor Pathophysiology: a Systematic Review.

Sara Pietracupa, Matteo Bologna, Silvia Tommasin, Alfredo Berardelli, Patrizia Pantano

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Cerebellum (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. A transdiagnostic structural brain signature of Parkinsonian and Essential Tremor.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  3. Article
  4. Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Erroneous Compensation for Long-Latency Feedback Delays as Origin of Essential Tremor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sara PietracupaIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, Italy. sara.pietracupa@uniroma1.it.ORCID http://orcid.org/0000-0002-7654-291X
Matteo BolognaIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, Italy.
Silvia TommasinDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Alfredo BerardelliIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, Italy.
Patrizia PantanoIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, Italy.
Istituto Neurologico Mediterraneo · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Essential tremor (ET) is one of the most common movement disorders. Over the last 10 years, magnetic resonance imaging (MRI) has shed light on the structural and functional abnormalities possibly involved in ET pathophysiology. In this systematic review, we aimed to identify the cortical and subcortical structures involved and the role that different brain areas play in the pathophysiology of motor and non-motor ET features. We found that structural (grey and white matter) cerebellar damage and connectivity alterations between the cerebellum and various cortical areas play a role in both motor and non-motor symptoms of ET. In particular, many studies found an association between MRI findings and non-motor symptoms.

Indexed as

Essential TremorBrainCerebellumHumansMagnetic Resonance ImagingNeuroimagingEssential tremorGrey matterMagnetic resonance imagingMRI functionalSystematic reviewWhite matter

Identifiers

PMID34657271
OpenAlexW3205233043

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.