Evidence map›Paper›PMID 34657194›Full record

ArticleCancer immunology, immunotherapy : CII2022

PD-1 blockade therapy augments the antitumor effects of lymphodepletion and adoptive T cell transfer.

Miho Takahashi, Satoshi Watanabe, Ryo Suzuki, Masashi Arita, Ko Sato, Miyuki Sato, Yuki Sekiya, Yuko Abe, Toshiya Fujisaki, Aya Ohtsubo and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Miho TakahashiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Satoshi WatanabeDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan. satoshi7@med.niigata-u.ac.jp.ORCID http://orcid.org/0000-0003-0041-6981
Ryo SuzukiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Masashi AritaDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Ko SatoDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Miyuki SatoDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Yuki SekiyaDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Yuko AbeDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Toshiya FujisakiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Aya OhtsuboDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Satoshi ShojiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Koichiro NozakiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Kosuke IchikawaDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Rie KondoDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Yu SaidaDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Satoshi HokariDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Nobumasa AokiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Masachika HayashiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Yasuyoshi OhshimaDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Toshiyuki KoyaDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Toshiaki KikuchiDepartment of Respiratory Medicine and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Niigata, Japan.
Niigata University · JPNiigata University Medical and Dental Hospital · JP

Funding

Japan society for promotion of science 24591157
6 · The paper itself

Abstract

Lymphodepleting cytotoxic regimens enhance the antitumor effects of adoptively transferred effector and naïve T cells. Although the mechanisms of antitumor immunity augmentation by lymphodepletion have been intensively investigated, the effects of lymphodepletion followed by T cell transfer on immune checkpoints in the tumor microenvironment remain unclear. The current study demonstrated that the expression of immune checkpoint molecules on transferred donor CD4

Indexed as

CD8-Positive T-LymphocytesNeoplasmsAdoptive TransferAnimalsHumansImmunotherapy, AdoptiveMiceProgrammed Cell Death 1 ReceptorTumor MicroenvironmentProgrammed Cell Death 1 ReceptorImmune checkpointLymphodepletionPD-1T cell

Identifiers

PMID34657194
PMCPMC10991227
OpenAlexW3207793419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.