Evidence map›Paper›PMID 34657180›Full record

ArticleJournal of neurology2022

Phoenix from the ashes: dramatic improvement in severe late-onset methylenetetrahydrofolate reductase (MTHFR) deficiency with a complete loss of vision.

Anne-Sophie Biesalski, Sabine Hoffjan, Ruth Schneider, Huu Phuc Nguyen, Gabriele Dekomien, Thomas Lücke, Christiane Schneider-Gold, Britta Matusche, Ralf Gold, Ilya Ayzenberg

Open access · hybridAbstract readCase ReportsLetter
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Doubly bi-allelic variants ofFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Anne-Sophie Biesalski *Department of Neurology, St. Josef Hospital, Gudrunstraße 56, 44791, Bochum, Germany. abiesalski@yahoo.de.ORCID http://orcid.org/0000-0002-1288-884X
Sabine Hoffjan *Department of Human Genetics, Ruhr-University, Bochum, Germany.
Ruth SchneiderDepartment of Neurology, St. Josef Hospital, Gudrunstraße 56, 44791, Bochum, Germany.
Huu Phuc NguyenDepartment of Human Genetics, Ruhr-University, Bochum, Germany.
Gabriele DekomienDepartment of Human Genetics, Ruhr-University, Bochum, Germany.
Thomas LückeUniversity Children's Hospital, St. Josef Hospital, Bochum, Germany.
Christiane Schneider-GoldDepartment of Neurology, St. Josef Hospital, Gudrunstraße 56, 44791, Bochum, Germany.
Britta MatuscheInstitute of Neuroradiology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Ralf GoldDepartment of Neurology, St. Josef Hospital, Gudrunstraße 56, 44791, Bochum, Germany.
Ilya AyzenbergDepartment of Neurology, St. Josef Hospital, Gudrunstraße 56, 44791, Bochum, Germany.
St. Josef-Hospital · DERuhr University Bochum · DESechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BlindnessHumansMethylenetetrahydrofolate Reductase (NADPH2)Muscle SpasticityMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, human

Identifiers

PMID34657180
PMCPMC8940754
OpenAlexW3205771427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.