ArticleHypertension research : official journal of the Japanese Society of Hypertension2022
Association of treatment-resistant hypertension defined by home blood pressure monitoring with cardiovascular outcome.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Ultrasound renal denervation for treatment-resistant hypertension with severe left ventricular hypertrophy.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Blood pressure management for stroke patients beyond the JSH 2025 guidelines.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Targeted approaches to diagnose and treat resistant hypertension in Asia.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Intensive blood pressure management in patients using multiple classes of antihypertensive drugs or with resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Resistant hypertension: diagnosis, evaluation, and treatment a clinical consensus statement from the Thai hypertension society.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Therapeutic intervention exploring hypertensive patients who respond to health coaching behavior modification therapy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Denervation or stimulation? Role of sympatho-vagal imbalance in HFpEF with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Clinical characteristics and outcomes of Chinese patients with coronary heart disease and resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Role of home blood pressure monitoring in resistant hypertension.Clinical hypertension · 2023Review
- Long-term blood pressure lowering effect of renal denervation and its patient preference, salt intake, and stroke in Asia.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Latest hypertension research to inform clinical practice in Asia.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Seven-action approaches for the management of hypertension in Asia - The HOPE Asia network.Journal of clinical hypertension (Greenwich, Conn.) · 2022Review
- Renal denervation: basic and clinical evidence.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Treatment-resistant hypertension assessed by home blood pressure monitoring: a new target for intervention?Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In diagnosis of treatment-resistant hypertension (TRH), guidelines recommend out-of-office blood pressure (BP) measurements, ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM). Although evidence of an association between ABPM-evaluated TRH and cardiovascular disease (CVD) prognosis has accumulated, data are sparse regarding HBPM-evaluated TRH. We investigated this issue using data from the nationwide practice-based J-HOP (Japan Morning-Surge Home BP) study, which recruited 4,261 outpatients (mean age 64.9 years; 46.8% men; 91.5% hypertensives) who underwent morning and evening HBPM for 14 days. During 6.2 ± 3.8 years (26,418 person-years) follow-up, 270 total CVDs (stroke, coronary artery disease, aortic dissection, and heart failure) occurred. The adjusted hazard ratio (HR) (95% CIs) of uncontrolled TRH, i.e., uncontrolled BP using 3 classes of medications including diuretics or ≥4 classes of medications, for total CVD risk compared to controlled BP using <3 classes were 2.02 (1.38-2.94) and 1.81 (1.23-2.65) in home BP of 135/85 mmHg and 130/80 mmHg, respectively. Additionally, patients with TRH defined by guidelines, i.e., uncontrolled BP using 3 classes of medications including diuretics or controlled/uncontrolled BP using ≥4 classes of medications, also had higher total CVD risk compared to non-TRH under all home BP criteria. Moreover, in patients with uncontrolled apparent-TRH, i.e., TRH defined by office BP, uncontrolled home BP (≥135/85 mmHg) was still associated with atherosclerotic CVD (CVDs except heart failure) risk (adjusted HR [95% CI], 2.38 [1.09-5.19]). This is the first study to demonstrate an independent association between TRH evaluated by HBPM and CVD outcomes.
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