ArticleNeuroImage2021
Investigating mechanisms of fast BOLD responses: The effects of stimulus intensity and of spatial heterogeneity of hemodynamics.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Model-based estimation of the population contrast response function in human visual cortex.Journal of vision · 2026Article
- BOLD response delays represent local cortical processing.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Sleep Alters the Velocity of Physiological Brain Pulsations in Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Frequency-specific resting state fMRI features in gliomas.Journal of neuro-oncology · 2026Article
- Biophysical simulations of fMRI responses using realistic microvascular models: Insights into distinct hemodynamics in humans and mice.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Steady-state free precession for TMagnetic resonance in medicine · 2025Article
- Towards whole brain mapping of the hemodynamic response function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.bioRxiv : the preprint server for biology · 2025Article
- Does the Cortical-Depth Dependence of the Hemodynamic Response Function Differ Between Age Groups?Brain topography · 2025Article
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Fast 3D fMRI acquisition with high spatial resolutions over a reduced FOV.Magnetic resonance in medicine · 2024Article
- Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging - A Symposium Review.Neuroinformatics · 2024Review
- Non-Cartesian 3D-SPARKLING vs Cartesian 3D-EPI encoding schemes for functional Magnetic Resonance Imaging at 7 Tesla.PloS one · 2024Article
- The temporal specificity of BOLD fMRI is systematically related to anatomical and vascular features of the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Whole-brain multivariate hemodynamic deconvolution for functional MRI with stability selection.Medical image analysis · 2024Article
- Characterizing systemic physiological effects on the blood oxygen level dependent signal of resting-state fMRI in time-frequency space using wavelets.Human brain mapping · 2023Article
- A selection and targeting framework of cortical locations for line-scanning fMRI.Human brain mapping · 2023Article
- Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.Neuroinformatics · 2023Article
- Functional ultrasound detects frequency-specific acute and delayed S-ketamine effects in the healthy mouse brain.Frontiers in neuroscience · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
Recent studies have demonstrated that fast fMRI can track neural activity well above the temporal limit predicted by the canonical hemodynamic response model. While these findings are promising, the biophysical mechanisms underlying these fast fMRI phenomena remain underexplored. In this study, we discuss two aspects of the hemodynamic response, complementary to several existing hypotheses, that can accommodate faster fMRI dynamics beyond those predicted by the canonical model. First, we demonstrate, using both visual and somatosensory paradigms, that the timing and shape of hemodynamic response functions (HRFs) vary across graded levels of stimulus intensity-with lower-intensity stimulation eliciting faster and narrower HRFs. Second, we show that as the spatial resolution of fMRI increases, voxel-wise HRFs begin to deviate from the canonical model, with a considerable portion of voxels exhibiting faster temporal dynamics than predicted by the canonical HRF. Collectively, both stimulus/task intensity and image resolution can affect the sensitivity of fMRI to fast brain activity, which may partly explain recent observations of fast fMRI signals. It is further noteworthy that, while the present investigations focus on fast neural responses, our findings suggest that a revised hemodynamic model may benefit the many fMRI studies using paradigms with wide ranges of contrast levels (e.g., resting or naturalistic conditions) or with modern, high-resolution MR acquisitions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.