ArticleJACC. Cardiovascular imaging2022
Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance.
Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase I
In one paragraph
Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07560306 ([64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy), which is not on this map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
[64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.Circulation · 2026Observational
- Cardiovascular imaging with total-body PET.The British journal of radiology · 2026Review
- Review
- Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans.Circulation. Cardiovascular imaging · 2025Article
- Delivery of a fibrin-binding hemostatic polymer ameliorates neurovascular damage and neural tissue loss after traumatic brain injury.Science advances · 2025Article
- Thrombus composition in ischaemic stroke: histological and radiological evaluation, and implications for acute clinical management.Journal of thrombosis and thrombolysis · 2025Review
- Evolving Strategies in the Detection and Management of Left Ventricular Thrombus: A Clinical Summary.Current cardiology reviews · 2025Review
- Development of a fibrin-targeted theranostic for gastric cancer.Science translational medicine · 2024Article
- Tuning the Properties of Rigidified Acyclic DEDPAInorganic chemistry · 2024Article
- Fibrin-Positron Emission Tomography Imaging Reveals Ongoing Lung Injury in Idiopathic Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2024Article
- X-ray Attenuating Vesicles with Neutrophil Extracellular Trap (NET) Specificity: Synthesis and Testing in a Model System.ACS omega · 2024Article
- Dosimetry of [medRxiv : the preprint server for health sciences · 2024Article
- Multi-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice.American heart journal plus : cardiology research and practice · 2024Article
- Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction.Pulmonary circulation · 2024Article
- Non-invasive in vivo imaging of changes in Collagen III turnover in myocardial fibrosis.Npj imaging · 2024Article
- Article
- Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Targeted Molecular Imaging Sheds Light on Bioprosthetic Aortic Valve Thrombosis.JACC. Cardiovascular imaging · 2022Article
- Imaging High-Risk Atherothrombosis Using a Novel Fibrin-Binding Positron Emission Tomography Probe.Stroke · 2022Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 2 institutions in 1 country.
David Izquierdo-GarciaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA; Harvard-MIT Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Electronic address: davidizq@nmr.mgh.harvard.edu.
Pauline DésogèreAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Anne L PhilipCardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Choukri MekkaouiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
Rory B WeinerCardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Onofrio A CatalanoAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
Yin-Ching Iris ChenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
Doreen DeFaria YehCardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Moussa MansourCardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ciprian CatanaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Peter CaravanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
David E SosnovikAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Massachusetts General Hospital · USHarvard University · US
Funding
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8MPET Imaging of ThrombusR01HL109448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, SOSNOVIK, DAVID E · 2011 to 2025
$9.6MMultimodal MR-PET Machine Learning Approaches for Primary Prostate Cancer CharacterizationR01CA218187 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CATANA, CIPRIAN · 2018 to 2023
$3.3MImaging Histone Deacetylase in the Heart and Bone MarrowR01HL141563 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SOSNOVIK, DAVID E · 2018 to 2021
$3.3MPET Imaging of Pulmonary FibrosisR01HL131907 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, LANUTI, MICHAEL · 2016 to 2018
$2.3MFree-Breathing Diffusion Tensor MRI in Patients Following Myocardial InfarctionR01HL131635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI · 2016 to 2020
$2.1MCombined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataS10RR022976 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE · 2007 to 2007
$2.0MPET CAMERA FOR BRAIN IMAGING: SCHIZOPHRENIA, BIPOLAR DISORDERS10RR019933 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$500kNCI NIH HHS R01 CA218187NCRR NIH HHS S10 RR019933NCRR NIH HHS S10 RR022976NHLBI NIH HHS R01 HL109448NHLBI NIH HHS R01 HL131635NHLBI NIH HHS R01 HL131907NHLBI NIH HHS R01 HL141563NIBIB NIH HHS P41 EB015896
Abstract
objectivesThe authors present a novel technique to detect and characterize LAA thrombus in humans using combined positron emission tomography (PET)/cardiac magnetic resonance (CMR) of a fibrin-binding radiotracer, [
backgroundThe detection of thrombus in the left atrial appendage (LAA) is vital in the prevention of stroke and is currently performed using transesophageal echocardiography (TEE).
methodsThe metabolism and pharmacokinetics of [
results[
conclusionsPET/CMR of [
Indexed as
Atrial AppendageThrombosisFibrinHumansMagnetic Resonance SpectroscopyPositron-Emission TomographyPredictive Value of TestsTomography, X-Ray ComputedFibrinatrial fibrillationfibrinleft atrial appendageMRIPETthrombus
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT07560306ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.