ArticleFertility and sterility2022
Associations between depression, oxidative stress, and semen quality among 1,000 healthy men screened as potential sperm donors.
Article in Fertility and sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review.Nutrients · 2024Pooled it
- Dyadic coping profiles and emotional distress in Chinese infertile couples.Scientific reports · 2026Article
- Disinfection Byproducts, Oxidative Stress, and Sleep Quality among Healthy Chinese Men.Environment & health (Washington, D.C.) · 2026Article
- Chronic stress drives oligoasthenozoospermia via gut microbiota-vitamin-Sting1/Slc9c2 axis.Nature communications · 2026Article
- Men's perceptions of long-term health outcomes following fertility problems: a UK-based mixed-methods survey.Journal of assisted reproduction and genetics · 2026Article
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
- Investigating the association between systemic immune-inflammation index and female fertility: a retrospective cohort study.Journal of ovarian research · 2026Article
- Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Organophosphate Flame Retardants, Obesity, and Depressive Symptoms among 1019 Young Healthy Men.Environment & health (Washington, D.C.) · 2025Article
- Detecting depression severity using weighted random forest and oxidative stress biomarkers.Scientific reports · 2024Article
- The association between serum magnesium and chronic kidney disease in Chinese adults: a cross-sectional study.BMC public health · 2024Article
- Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality.Frontiers in endocrinology · 2024Article
- Preconception depression reduces fertility: a couple-based prospective preconception cohort.Human reproduction open · 2024Article
- Factors associated with anxiety and depression in men undergoing fertility investigations: a cross-sectional study.BMC psychology · 2023Article
- Psychological status of infertile men during the Coronavirus Disease 2019 Pandemic in China: a cross-sectional investigation.Basic and clinical andrology · 2023Article
- Relationship Between Dyadic Coping with Anxiety and Depression in Infertile Couples: Gender Differences and Dyadic Interaction.Psychology research and behavior management · 2023Article
- Non-linear association between composite dietary antioxidant index and depression.Frontiers in public health · 2022Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the association between depression and semen quality and the mediating role of oxidative stress.
designCross-sectional study with repeated measures of semen quality.
settingHuman Sperm Bank of Hubei Province, People's Republic of China. PATIENT(S): From April 2017 to July 2018, we recruited 1,000 potential sperm donors who completed the Beck Depression Inventory questionnaire and had measures of oxidative stress biomarkers. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Severity of depression was evaluated by the Beck Depression Inventory scores (0-4, no depression; 5-13, mild depression; 14-20, moderate depression; and 21 or greater, severe depression). The urinary concentrations of 8-hydroxy-2-deoxyguanosine, 4-hydroxy-2-nonenal-mercapturic acid, and 8-iso-prostaglandin F RESULT(S): A total of 391 (39.1%) men were classified as mild depression, 67 (6.7%) as moderate depression, and 19 (1.9%) as severe depression. Inverse dose-response relationships between severity of depression and semen quality parameters were found. Compared with men without depression (n = 523), those with severe depression had a 25.26% (95% confidence interval, -38.65%, -8.93%) lower semen volume, 37.04% (-55.37%, -11.20%) lower total sperm count, 13.57% (-23.17%, -2.78%) lower total motility, and 15.08% (-25.09%, -3.72%) lower progressive motility; men with moderate depression also had a 12.28% (-21.16%, -2.40%) lower semen volume and 23.56% (-36.50%, -7.97%) lower total sperm count. We found a positive dose-response relationship between severity of depression and urinary 8-isoPGF CONCLUSION(S): In the study of Chinese male sperm donors, men with depression had worse semen quality parameters, including semen volume, sperm concentration, total sperm count, total motility, and progressive motility. Although depression was positively associated with urinary 8-isoPGF
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