Evidence map›Paper›PMID 34656192›Full record

Trial reportBehavior therapy2021

The Nature, Timing, and Symptom Trajectories of Dropout From Transdiagnostic and Single-Diagnosis Cognitive-Behavioral Therapy for Anxiety Disorders.

Kate H Bentley, Zachary D Cohen, Thomas Kim, Jacqueline R Bullis, Maya Nauphal, Clair Cassiello-Robbins, Shannon Sauer-Zavala, Sophia Sbi, Matthew W Gallagher, Todd J Farchione and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Behavior therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Music Therapy Versus Cognitive Behavioral Therapy via Telehealth for Anxiety in Survivors of Cancer: A Randomized Clinical Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Trial
  2. Trial
  3. Trial
  4. Article
  5. Accelerated Unified Protocol for Transdiagnostic Treatment of Anxiety Disorders in a VHA System.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kate H BentleyMassachusetts General Hospital/Harvard Medical School. Electronic address: kbentley@mgh.harvard.edu.
Zachary D CohenUniversity of California Los Angeles.
Thomas KimUniversity of Pennsylvania.
Jacqueline R BullisMcLean Hospital/Harvard Medical School.
Maya NauphalCenter for Anxiety and Related Disorders, Boston University.
Clair Cassiello-RobbinsDuke University Medical Center.
Shannon Sauer-ZavalaUniversity of Kentucky.
Sophia SbiPacific University.
Matthew W GallagherUniversity of Houston.
Todd J FarchioneCenter for Anxiety and Related Disorders, Boston University.
David H BarlowCenter for Anxiety and Related Disorders, Boston University.

Funding

Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety DisordersR01MH090053 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BARLOW, DAVID H. · 2011 to 2015
$2.9M
Digital Monitoring of Agitation for Short-Term Suicide Risk PredictionK23MH120436 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BENTLEY, KATE H. · 2019 to 2024
$1.0M
NIMH NIH HHS K23 MH120436NIMH NIH HHS R01 MH090053
6 · The paper itself

Abstract

Dropout from psychotherapy is common and can have negative effects for patients, providers, and researchers. A better understanding of when and why patients stop treatment early, as well as actionable factors contributing to dropout, has the potential to prevent it. Here, we examined dropout from a large randomized controlled trial of transdiagnostic versus single-diagnosis cognitive-behavioral treatment (CBT) for patients with anxiety disorders (n = 179; Barlow et al., 2017). We aimed to characterize the timing of and reasons for dropout and test whether participants who dropped out had different symptom trajectories than those who completed treatment. Results indicated that overall, the greatest risk of dropout was prior to the first treatment session. In single-diagnosis CBT, dropout risk was particularly elevated before the first session and after other early sessions, whereas in transdiagnostic CBT, dropout risk was low and stable before and during treatment. Participants most often dropped out due to failure to comply with study procedures or dissatisfaction with or desiring alternative treatment. Results from multilevel models showed that trajectories of anxiety symptoms did not significantly differ between dropouts and completers. These findings suggest that there may be specific time windows for targeted and timely interventions to prevent dropout from CBT.

Indexed as

Cognitive Behavioral TherapyPatient DropoutsAnxiety DisordersHumansPsychotherapyTreatment OutcomeattritionCBTcognitive-behavioral therapydropouttransdiagnostic

Identifiers

PMID34656192
PMCPMC8531532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.