Evidence map›Paper›PMID 34656180›Full record

ArticleInternational journal of retina and vitreous2021

Safety of various parameter sets with navigated microsecond pulsing laser in central serous chorioretinopathy.

Jay Chhablani, Gagan Kalra, Lubna Alkwatli, Bernd Fassbender, Francesca Amoroso, Khushboo Chandra, Samantha Ankireddy, Dmitrii Maltsev, Nina-Antonia Striebe, Eric Souied

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Article in International journal of retina and vitreous, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jay ChhablaniLV Prasad Eye Institute, Hyderabad, India. jay.chhablani@gmail.com.ORCID http://orcid.org/0000-0003-1772-3558
Gagan KalraCole Eye Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Lubna AlkwatliGiers, V. Lovenberg-Prömper, Fassbender, Detmold, Germany.
Bernd FassbenderGiers, V. Lovenberg-Prömper, Fassbender, Detmold, Germany.
Francesca AmorosoCentre Hospitalier Intercommunal de Creteil, Paris, France.
Khushboo ChandraLV Prasad Eye Institute, Hyderabad, India.
Samantha AnkireddySchool of Medicine, University of Missouri-Kansas City, Kansas, MI, USA.
Dmitrii MaltsevDepartment of Ophthalmology, Military Medical Academy, St. Petersburg, Russia.
Nina-Antonia StriebeUniversity Clinic, Göttingen, Germany.
Eric SouiedCentre Hospitalier Intercommunal de Creteil, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubthreshold microsecond pulsing laser is an increasingly common treatment approach for central serous chorioretinopathy. However, there is no literature available on the safety of microsecond laser using different fluence settings in this disease. While many publications can be obtained from conventional microsecond pulsing lasers, few parameter sets are published with the navigated microsecond pulsing laser. Therefore, this study aims to investigate the safety of different parameter sets in subthreshold microsecond pulsing laser treatments.

methodsIn this retrospective chart review, consecutive patients with central serous chorioretinopathy (> 3 months duration of symptoms) treated with navigated subthreshold microsecond pulsing laser and a follow up of at least five months after microsecond laser application were included. For each patient, the treatment parameters, plan layout, and adverse events related to laser were evaluated. Secondary outcomes included best-corrected visual acuity and anatomical improvements (central retinal thickness).

resultsOne hundred and one eyes were included in the observation and followed for a mean of 10 months (range 5-36). Although a larger range of parameter sets and fluence settings have been used, no patient demonstrated adverse events from navigated microsecond pulsing laser. While 88% of the cases demonstrated stability, 13 cases lost five or more letters due to the persistence of the subretinal fluid. In mean, a best-corrected visual acuity improvement of 0.07logMar (± 0.2) was seen (p = 0.02). In 51% of the patients, a statistically significant improvement of the central retinal thickness was noted at the last follow-up with a mean thickness reduction of 70 µm (± 143) (p < 0.01).

conclusionIn conclusion, none of the used parameter sets lead to tissue damage (when using a cautious titration) and, in summary, lead to an improvement in subretinal fluid and improvement in visual acuity. However, further prospective studies are needed to correctly identify the dependency of the treatment strategy on the outcome criteria.

Indexed as

CSCRNavigated microsecond pulsing laserSafetySubthreshold

Identifiers

PMID34656180
PMCPMC8520234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.