Evidence map›Paper›PMID 34656134›Full record

ArticleAIDS research and therapy2021

Tocilizumab in HIV patient with severe COVID-19: case report.

Pedro Vieira Bertozzi, Amanda de Oliveira Vicente, Amanda Siqueira Pereira, Joao Pedro Espinha de Sant'Ana, Rafaela Braga Cabrera Mano, Luciana Souza Jorge, Rodrigo Afonso da Silva Sardenberg

Open access · goldAbstract readCase Reports
In one paragraph

Article in AIDS research and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Role of epinephrine in attenuating cytokine storm, decreasing ferritin, and inhibiting ferroptosis in SARS-CoV-2.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Pedro Vieira BertozziAdvanced Research Center in Medicine, Uniao das Faculdades dos Grandes Lagos-UNILAGO, Emilia Tarraf st., 340, São Jose do Rio Preto, SP, 15055-460, Brazil. pedro.vieira.1998@hotmail.com.
Amanda de Oliveira VicenteAdvanced Research Center in Medicine, Uniao das Faculdades dos Grandes Lagos, UNILAGO, São Jose do Rio Preto, SP, Brazil.
Amanda Siqueira PereiraAdvanced Research Center in Medicine, Uniao das Faculdades dos Grandes Lagos, UNILAGO, São Jose do Rio Preto, SP, Brazil.
Joao Pedro Espinha de Sant'AnaAdvanced Research Center in Medicine, Uniao das Faculdades dos Grandes Lagos, UNILAGO, São Jose do Rio Preto, SP, Brazil.
Rafaela Braga Cabrera ManoAdvanced Research Center in Medicine, Uniao das Faculdades dos Grandes Lagos, UNILAGO, São Jose do Rio Preto, SP, Brazil.
Luciana Souza JorgeInfectology Department, Hospital de Base, São Jose do Rio Preto, Brazil.
Rodrigo Afonso da Silva SardenbergAdvanced Research Center in Medicine, Uniao das Faculdades dos Grandes Lagos, UNILAGO, São Jose do Rio Preto, SP, Brazil.
Faculdade Ceres · BRHospital Alemão Oswaldo Cruz · BRHospital de Base · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. CASE PRESENTATION: The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient's condition.

conclusionThe patient had several risk factors, such as male gender, age  >  70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient's recovery since the drug increased his immune response, which is deficient, due to HIV infection.

Indexed as

COVID-19 Drug TreatmentHIV InfectionsAgedAntibodies, Monoclonal, HumanizedHumansMaleAntibodies, Monoclonal, HumanizedtocilizumabCase reportCoinfectionCOVID-19HIVTocilizumab

Identifiers

PMID34656134
PMCPMC8520187
OpenAlexW3206918769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.