ArticleReproductive biology and endocrinology : RB&E2021
Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes.
Article in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Average oocyte quality index as a method for scoring dysmorphic oocytes in women with ovarian endometrioma undergoing in vitro fertilization and its correlation with ovarian reserve.Clinical and experimental reproductive medicine · 2026Article
- Article
- Endometriosis disrupts oocyte metabolism and cortical granule function, impairing fertilization.Reproductive biology and endocrinology : RB&E · 2026Article
- Review
- Clinical challenges and therapeutic strategies in women with endometriosis, deep infiltrating endometriosis, and/or adenomyosis undergoing assisted reproductive technologies: a narrative review.Frontiers in reproductive health · 2026Review
- Beyond oocyte quantity: the paradoxical role of poor ovarian response in live birth outcomes among endometriosis patients undergoing IVF/ICSI-ET.Journal of assisted reproduction and genetics · 2025Article
- In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis.Biology · 2025Review
- The Effects of Endometriosis on Oocyte and Embryo Quality.Journal of clinical medicine · 2025Review
- Molecular Profile (Estrogen Receptor, Progesterone Receptor, Bcl-2 and Ki-67) of the Ectopic Endometrium in Patients with Endometriosis.International journal of molecular sciences · 2025Article
- Comparison of success rates in early stages of in vitro fertilization (IVF) in women with and without endometriosis.Narra J · 2024Article
- Review
- Article
- Endometriosis and In Vitro Fertilization.Medicina (Kaunas, Lithuania) · 2024Review
- Clinical and laboratory factors associated with the presence of dysmorphic oocytes in intracytoplasmic sperm injection cycles.Clinical and experimental reproductive medicine · 2023Article
- Endometriosis, Oocyte, and Embryo Quality.Journal of clinical medicine · 2023Review
- Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells.Frontiers in endocrinology · 2023Review
- Oocyte Cryopreservation in Patients with Endometriosis: Current Knowledge and Number Needed to Treat.Journal of clinical medicine · 2022Review
- Is Oocyte Quality Impaired in Cases With Ovarian Endometriosis? A Second Look Into the Clinical Setting.Frontiers in endocrinology · 2022Article
- Investigating Unilateral Ovarian Endometrioma's Effect on Ova and Embryo Quality in 409 Infertile Endometriotic Patients.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfertility associated with endometriosis can be explained by several non-exclusive mechanisms. The oocyte plays a crucial role in determining embryonic competence and this is particularly relevant for in vitro fertilization (IVF) outcomes. According to some authors, the morphology of oocytes could also be a non-invasive marker of oocyte quality. The aim of this study was to evaluate the relationship between endometriosis and oocyte morphology after controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI) on a large oocyte cohort.
methodsSingle-center comparative retrospective study in the academic In Vitro Fertilization (IVF) unit of the Lille University Hospital. A total of 596 women treated for IVF-ICSI with ejaculated spermatozoa for sperm alterations were included. They were classified as endometriosis (n = 175) or control groups (n = 401). The morphological evaluation of 2,016 mature oocytes from 348 cycles of patients with endometriosis was compared with that of 4,073 mature oocytes from 576 control cycles. The main outcome measures were Average Oocyte Quality Index (AOQI) and metaphase II oocyte morphological scoring system (MOMS). Comparison of groups was carried out by a mixed linear model and by a generalized estimation equation model with a "patient" random effect to consider that a patient might have several attempts.
resultsNo difference in AOQI and MOMS scores was found between endometriosis and control women (adjusted p = 0.084 and 0.053, respectively). In case of endometriosis, there were significantly fewer metaphase II oocytes retrieved, embryos obtained, grade 1 embryos and number of cumulative clinical pregnancies compared to controls. In the endometriosis group, endometriosis surgery was associated with a reduced number of mature oocytes retrieved, and the presence of endometrioma(s) was associated with some abnormal oocyte shapes. Nevertheless, no difference concerning the AOQI and MOMS scores was found in these subgroups.
conclusionEndometriosis does not have a negative impact on oocytes' morphology in IVF-ICSI.
trial registrationOn December 16, 2019, the Institutional Review Board of the Lille University Hospital gave unrestricted approval for the anonymous use of all patients' clinical, hormonal and ultrasound records (reference DEC20150715-0002).
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