ArticleJournal of affective disorders2022
Genetic risk for psychiatric illness is associated with the number of hospitalizations of bipolar disorder patients.
Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- The impact of collider bias on genetic prediction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Where is mania in the meta-structure of psychopathology?Psychological medicine · 2025Article
- Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder.Molecular psychiatry · 2024Article
- White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls - exploring associations with disease course and polygenic risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Mental disorders and discrimination: A prospective cohort study of young twin pairs in Germany.SSM - population health · 2024Article
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Authors and funding
37 authors at 12 institutions in 6 countries.
Funding
Abstract
objectivesBipolar disorder (BD) has a highly heterogeneous clinical course that is characterized by relapses and increased health care utilization in a significant fraction of patients. A thorough understanding of factors influencing illness course is essential for predicting disorder severity and developing targeted therapies.
methodsWe performed polygenic score analyses in four cohorts (N = 954) to test whether the genetic risk for BD, schizophrenia, or major depression is associated with a severe course of BD. We analyzed BD patients with a minimum illness duration of five years. The severity of the disease course was assessed by using the number of hospitalizations in a mental health facility and a composite measure of longitudinal illness severity (OPCRIT item 90).
resultsOur analyses showed that higher polygenic scores for BD (β = 0.11, SE = 0.03, p = 1.17 × 10 LIMITATIONS: We could not account for non-genetic influences on disease course. Our clinical sample contained more severe cases.
conclusionsThis study demonstrates that the genetic risk burden for psychiatric illness is associated with increased health care utilization, a proxy for disease severity, in BD patients. The findings are in line with previous observations made for patients diagnosed with schizophrenia or major depression. Therefore, in the future psychiatric disorder polygenic scores might become helpful for stratifying patients with high risk of a chronic manifestation and predicting disease course.
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