Evidence map›Paper›PMID 34656039›Full record

ArticleJournal of affective disorders2022

Comparing mortality from covid-19 to mortality due to overdose: A micromort analysis.

Yena Lee, Leanna M W Lui, Elisa Brietzke, Yuhua Liao, Ciyong Lu, Roger Ho, Mehala Subramaniapillai, Rodrigo B Mansur, Joshua D Rosenblat, Roger S McIntyre

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Observational
  2. Identifying the Changing Landscape of Younger Adult Mortality in the United States from 1999 to 2021.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
    Observational
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  9. Canadian blood suppliers: An expanding role in public health surveillance?Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022
    Article
  10. Characteristics of suicidal poisoned patients admitted to tertiary care center during COVID-19 pandemic.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Yena LeeMood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, M5T 2S8; Institute of Medical Science, University of Toronto, Toronto, ON, Canada, M5S 1A8. Electronic address: yenalee.lee@utoronto.ca.
Leanna M W LuiMood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, M5T 2S8. Electronic address: leanna.lui@mail.utoronto.ca.
Elisa BrietzkeDepartment of Psychiatry, Queen's University School of Medicine, Kingston, ON, Canada; Centre for Neuroscience Studies (CNS), Queen's University, Kingston, ON, Canada. Electronic address: elisa.brietzke@queensu.ca.
Yuhua LiaoDepartment of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, China; Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
Ciyong LuDepartment of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, China. Electronic address: luciyong@mail.sysu.edu.cn.
Roger HoDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore. Electronic address: roger_ho@nuhs.edu.sg.
Mehala SubramaniapillaiMood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, M5T 2S8. Electronic address: m.subram@mail.utoronto.ca.
Rodrigo B MansurMood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, M5T 2S8; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, M5S 1A8. Electronic address: rodrigo.mansur@uhn.ca.
Joshua D RosenblatMood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, M5T 2S8; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, M5S 1A8. Electronic address: joshua.rosenblat@uhn.ca.
Roger S McIntyreMood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, M5T 2S8; Institute of Medical Science, University of Toronto, Toronto, ON, Canada, M5S 1A8; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, M5S 1A8; Department of Pharmacology, University of Toronto, Toronto, ON, Canada, M5S 1A8. Electronic address: roger.mcintyre@uhn.ca.
University Health Network · CASun Yat-sen University · CNNational University of Singapore · SGQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the mortality risk due to covid-19 with death due to overdose in British Columbia, Canada. The opioid epidemic was declared a public health emergency in 2016.

methodsMortality risk was calculated in micromorts with covid-19 data for January-October 2020, derived from the BC center for Disease Control, and illicit drug toxicity deaths for January 2010-September 2020, derived from the BC Coroners Service. Age-stratified covid-19 incidence and deaths per 100,000 population and age-stratified illicit drug toxicity death rates per 100,000 population were calculated. A micromort is a unit of risk equivalent to a one-in-a-million chance of death.

resultsDuring the covid-19 pandemic, illicit drug toxicity deaths reached 1.0 micromorts per day, representing an increase of 0.5 micromorts per day relative to 2019 rates. In comparison, covid-19 mortality risk was 0.05 micromorts per day among individuals from the general population living in British Columbia and 21.1 micromorts per day among those infected with covid-19. Covid-related mortality risk was significantly lower among individuals aged <60 years, relative to older adults, whereas drug toxicity-related mortality was highest for individuals aged 30-59 years.

conclusionsThe mortality associated with covid-19 is apparent and distributed unevenly across subpopulations. The mortality due to overdose has increased during covid-19 and exceeds mortality due to covid-19. Our results instantiate the triple threat caused by covid-19 (i.e., public health crisis, economic crisis and mental health crisis) and quantitatively highlight the externality of increased mortality due to deaths of despair in response to public health efforts to reduce covid-related mortality.

Indexed as

COVID-19Drug OverdoseAgedBritish ColumbiaHumansPandemicsSARS-CoV-2Age GroupsBritish ColumbiaCanadaComorbidityCoronavirus InfectionsCOVID-19DepressionDepressive DisorderDrug OverdoseEpidemicsEpidemiologyGlobal HealthHumansLonelinessMental HealthMicromortMiddle AgedMood DisordersMortalityMortality rateOpioidOpioid EpidemicOutcome and Process Assessment, Health CarePandemicsPandemics / prevention & control*Population HealthPublic healthPublic HealthPublic PolicyResilienceRiskSevere acute respiratory syndrome coronavirus 2Social MedicineSubstance abuseSuicideUnemploymentWell-being

Identifiers

PMID34656039
PMCPMC8461265
OpenAlexW3202968177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.