Evidence map›Paper›PMID 34655995›Full record

ArticleRedox biology2021

Novel role of xanthine oxidase-dependent H

Suresh Govatati, Prahalathan Pichavaram, Arul M Mani, Raj Kumar, Deepti Sharma, Ari Dienel, Sunita Meena, Michelle A Puchowicz, Edwards A Park, Gadiparthi N Rao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. iScience · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Suresh GovatatiDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Prahalathan PichavaramDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Arul M ManiDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Raj KumarDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Deepti SharmaDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Ari DienelDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Sunita MeenaDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Michelle A PuchowiczDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Edwards A ParkDepartment of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Gadiparthi N RaoDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. Electronic address: rgadipar@uthsc.edu.
University of Tennessee Health Science Center · US

Funding

Secretory phospholipase A2 enhances metabolic rateI01BX002408 · VA · MEMPHIS VA MEDICAL CENTER · PI PARK, EDWARDS A · 2015 to 2024
–
BLRD VA I01 BX002408
6 · The paper itself

Abstract

12/15-lipoxygenase (12/15-LOX) plays an essential role in oxidative conversion of polyunsaturated fatty acids into various bioactive lipid molecules. Although 12/15-LOX's role in the pathophysiology of various human diseases has been well studied, its role in weight gain is controversial and poorly clarified. Here, we demonstrated the role of 12/15-LOX in high-fat diet (HFD)-induced weight gain in a mouse model. We found that 12/15-LOX mediates HFD-induced de novo lipogenesis (DNL), triglyceride (TG) biosynthesis and the transport of TGs from the liver to adipose tissue leading to white adipose tissue (WAT) expansion and weight gain via xanthine oxidase (XO)-dependent production of H

Indexed as

LipogenesisXanthine OxidaseAnimalsArachidonate 15-LipoxygenaseDiet, High-FatHydrogen PeroxideLiverMiceTriglyceridesWeight GainArachidonate 15-LipoxygenaseHydrogen PeroxideTriglyceridesXanthine Oxidase12/15-Lipoxygenasede novo lipogenesisHydrogen peroxideTriglyceride biosynthesisWeight gainXanthine oxidase

Identifiers

PMID34655995
PMCPMC8577505
OpenAlexW3206556964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.