ArticleNeurobiology of aging2022
Regional age-related atrophy after screening for preclinical alzheimer disease.
Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Divergent Multimodal Age-Association Profiles Across the Human Brain.Nature communications · 2026Article
- Neighborhood greenspace and brain imaging outcomes in older adults without dementia from three US Alzheimer's Disease Research Centers.Health & place · 2026Article
- Regional Cerebrospinal Fluid Motility as a Key Determinant of Soluble Amyloid-β Levels and Kinetics.Research square · 2026Article
- Structural MRI in frontotemporal dementia and Alzheimer's disease: stage-dependent atrophy patterns.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Frontal Lobe and Subregional Volumetric Alterations Across Alzheimer's Disease, Amnestic Mild Cognitive Impairment, and Vascular Dementia: An MRI Volumetry Study.Brain sciences · 2026Article
- Joint effects of sleep behaviors and physical activity on brain structure and cognitive function.Fundamental research · 2026Article
- Elevated functional magnetic resonance imaging activity in cognitively normal participants predicts future dementia.Brain communications · 2026Article
- Coupled Aging of Cyto- and Myeloarchitectonic Atlas-Informed Gray and White Matter Structural Properties.Human brain mapping · 2025Article
- Whole-genome sequencing reveals the impact of lipid pathway and APOE genotype on brain amyloidosis.Human molecular genetics · 2025Article
- Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study.Frontiers in aging neuroscience · 2025Article
- T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease.Human brain mapping · 2023Observational
- Disrupted excitation-inhibition balance in cognitively normal individuals at risk of Alzheimer's disease.bioRxiv : the preprint server for biology · 2023Article
- Cortical atrophy and leukoaraiosis, imaging markers of cerebrovascular small vessel disease, are associated with driving behavior changes among cognitively normal older adults.Journal of the neurological sciences · 2023Article
- Aging and Alzheimer's disease have dissociable effects on local and regional medial temporal lobe connectivity.Brain communications · 2023Article
- Disrupted Excitation-Inhibition Balance in Cognitively Normal Individuals at Risk of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Cognitive and brain reserve predict decline in adverse driving behaviors among cognitively normal older adults.Frontiers in psychology · 2022Article
- Homotopic functional connectivity disruptions in glioma patients are associated with tumor malignancy and overall survival.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 3 countries.
Funding
Abstract
Brain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was seen in nearly all regions, with greatest effects in the temporal lobe and subcortical regions. When modeling age with the estimated derivative of smoothed aging curves, we found that the temporal lobe declined linearly with age, subcortical regions declined faster at later ages, and frontal regions declined slower at later ages than during midlife. This age-derivative pattern was distinct from the linear measure of age-related atrophy and significantly associated with a measure of myelin. Atrophy did not detectably differ from a preclinical Alzheimer disease cohort when age ranges were matched.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.