ArticleBreast (Edinburgh, Scotland)2021
Unique challenges and outcomes of young women with breast cancers from a tertiary care cancer centre in India.
Article in Breast (Edinburgh, Scotland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Global Disparities in Insurance Coverage of Post-Mastectomy Breast Reconstruction.Annals of surgical oncology · 2026Review
- Factors Driving Low Rates of Post-Mastectomy Breast Reconstruction in Low- and Middle-Income Countries: A Systematic Review.Journal of plastic and reconstructive surgery · 2026Review
- Deep learning on histopathological images to predict breast cancer recurrence risk and chemotherapy benefit: a multicentre, model development and validation study.The Lancet. Oncology · 2026Article
- Breast Cancer Screening in Asian Countries: Epidemiology, Screening Practices, Outcomes, Challenges, and Future Directions.Korean journal of radiology · 2025Review
- Global, regional, and national burden of breast cancer in young women from 1990 to 2021: findings from the global burden of disease study 2021.BMC cancer · 2025Article
- Article
- Clinical profile and outcomes of young women with denovo-metastatic breast cancer: real-world data from a tertiary care centre in India.Ecancermedicalscience · 2025Article
- Article
- Unveiling the Clinicopathological Outcomes of Breast Cancer in Young Women:Sultan Qaboos University medical journal · 2025Article
- Tumour biology and survival outcomes in young women with breast cancer: single-centre retrospective analysis.BJS open · 2024Article
- Caring Connections: Unveiling Supportive Needs for Enhanced Quality of Life in Young Women with Breast Cancer.Journal of caring sciences · 2024Article
- A Glimpse into the Epidemiology of Geriatric Cancers in India: Report from the Indian Population Based Cancer Registries.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Understanding the Rising Breast Cancer Among Young Women: Biological Insights, Projections, and an Opportunity Window Leading up to 2040.Indian journal of surgical oncology · 2024Article
- Diagnostic delays in breast cancer among young women: An emphasis on healthcare providers.Breast (Edinburgh, Scotland) · 2024Article
- Management ofEcancermedicalscience · 2024Review
- Oncofertility and Pregnancy in Adolescent and Young Adult Cancers: Physicians' Knowledge and Preferences in India.JCO global oncology · 2024Article
- Breast cancer in young Indian women: factors, challenges in screening, and upcoming diagnostics.Journal of cancer research and clinical oncology · 2023Review
- Efficacy of post‑mastectomy radiotherapy in patients with T1‑2N1 breast cancer aged ≤35 years or with a positive HER‑2 status.Molecular and clinical oncology · 2023Article
- What Is Known about Breast Cancer in Young Women?Cancers · 2023Review
- Breast cancer: miRNAs monitoring chemoresistance and systemic therapy.Frontiers in oncology · 2023Review
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundYoung (≤40 years) breast cancers (YBC) are uncommon, inadequately represented in trials and have unique concerns and merit studying.
methodsThe YBC treated with a curative intent between 2015 and 2016 at our institute were analysed.
resultsThere were 1228 patients with a median age of 36 (12-40) years; 38 (3.1%) had Stage I, 455 (37.1%) - II, 692 (56.3%) -III, and remaining 43 (3.5%) Stage IV (oligo-metastatic) disease; 927 (75.5%) were node positive; 422 (34.4%) were Triple negatives (TNBC), 331 (27%) were HER-2 positive. There were 549 (48.2%) breast conservations and 591 (51.8%) mastectomies of which 62 (10.4%) underwent breast reconstruction. 1143 women received chemotherapy, 617 (53.9%) received as neoadjuvant and 142 (23.1%) had pathological complete response; 934 (81.9%) received adjuvant radiotherapy. At the median follow-up of 48 (0-131) months, 5-year overall and disease-free survival was 79.6% (76.8-82.5) and 59.1% (55.8-62.6). For stage I, II, III and IV, the 5-year overall-survival was 100%, 86.7% (82.8-90.6), 77.3% (73.4-81.2), 69.7% (52.5-86.9) and disease-free survival was 94% (85.9-100), 65.9% (60.3-71.5), 55% (50.5-59.5), and 29.6% (14-45.2) respectively. On multivariate analysis, TNBC and HER-2+ subgroups had poorer survival (p = 0.0035). 25 patients had BRCA mutations with a 5-year DFS of 65.1% (95% CI:43.6-86.6). Fertility preservation was administered in 104 (8.5%) patients; seven women conceived and 5 had live births. Significant postmenopausal symptoms were present in 153 (13%) patients.
conclusionMore than half of the YBC in India were diagnosed at an advanced stage with aggressive features leading to suboptimal outcomes. Awareness via national registry and early diagnosis is highly warranted. Menopausal symptoms and fertility issues are prevalent and demand special focus.
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