Evidence map›Paper›PMID 34655869›Full record

ArticleJournal of hazardous materials2022

Understanding and managing uncertainty and variability for wastewater monitoring beyond the pandemic: Lessons learned from the United Kingdom national COVID-19 surveillance programmes.

Matthew J Wade, Anna Lo Jacomo, Elena Armenise, Mathew R Brown, Joshua T Bunce, Graeme J Cameron, Zhou Fang, Kata Farkas, Deidre F Gilpin, David W Graham and 21 more

Abstract read
In one paragraph

Article in Journal of hazardous materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Matthew J WadeUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; Newcastle University, School of Engineering, Cassie Building, Newcastle-upon-Tyne NE1 7RU, UK. Electronic address: matthew.wade@dhsc.gov.uk.
Anna Lo JacomoUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; Bristol University, Department of Engineering Mathematics, Bristol BS8 1TW, UK.
Elena ArmeniseEnvironment Agency, Research, Horizon House, Deanery Road, Bristol BS1 5AH, UK.
Mathew R BrownUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; Newcastle University, School of Engineering, Cassie Building, Newcastle-upon-Tyne NE1 7RU, UK.
Joshua T BunceUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; Newcastle University, School of Engineering, Cassie Building, Newcastle-upon-Tyne NE1 7RU, UK; Department for Environment, Food and Rural Affairs, Seacole Building, 2 Marsham Street, London SW1P 4DF, UK.
Graeme J CameronScottish Environment Protection Agency, Strathallan House, Stirling FK9 4TZ, UK.
Zhou FangBiomathematics and Statistics Scotland, James Clerk Maxwell Building, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UK.
Kata FarkasBangor University, School of Natural Sciences, Deiniol Road, Bangor LL57 2UW, UK.
Deidre F GilpinQueen's University Belfast, School of Pharmacy, Lisburn Road, Belfast BT9 7BL, UK.
David W GrahamNewcastle University, School of Engineering, Cassie Building, Newcastle-upon-Tyne NE1 7RU, UK.
Jasmine M S GrimsleyUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK.
Alwyn HartEnvironment Agency, Research, Horizon House, Deanery Road, Bristol BS1 5AH, UK.
Till HoffmannUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; Imperial College London, Department of Mathematics, London SW7 2AZ, UK.
Katherine J JacksonEnvironment Agency, Research, Horizon House, Deanery Road, Bristol BS1 5AH, UK.
David L JonesBangor University, School of Natural Sciences, Deiniol Road, Bangor LL57 2UW, UK; The University of Western Australia, UWA School of Agriculture and Environment, Perth, WA 6009, Australia.
Chris J LilleyUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK.
John W McGrathQueen's University Belfast, School of Biological Sciences, Chlorine Gardens, Belfast BT9 5DL, UK.
Jennifer M McKinleyQueen's University Belfast, School of Natural and Built Environment, Stranmills Road, Belfast BT9 5AG, UK.
Cormac McSparronQueen's University Belfast, School of Natural and Built Environment, Stranmills Road, Belfast BT9 5AG, UK.
Behnam F NejadQueen's University Belfast, School of Natural and Built Environment, Stranmills Road, Belfast BT9 5AG, UK.
Mario MorvanUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; University College London, Department of Physics and Astronomy, Gower Street, London WC1E 6BT, UK.
Marcos Quintela-BalujaNewcastle University, School of Engineering, Cassie Building, Newcastle-upon-Tyne NE1 7RU, UK.
Adrian M I RobertsBiomathematics and Statistics Scotland, James Clerk Maxwell Building, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UK.
Andrew C SingerUK Centre for Ecology and Hydrology, Benson Lane, Wallingford OX10 8BB, UK.
Célia SouqueUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; University of Oxford, Department of Zoology, Mansfield Road, Oxford OX1 3SZ, UK.
Vanessa L SpeightUniversity of Sheffield, Department of Civil and Structural Engineering, Mappin Street, Sheffield S1 3JD, UK.
Chris SweetappleUK Health Security Agency, Environmental Monitoring for Health Protection, Windsor House, Victoria Street, London SW1H 0TL, UK; University of Exeter, Centre for Water Systems, College of Engineering, Mathematics and Physical Sciences, Exeter EX4 4QF, UK.
David WalkerCentre for Environment, Fisheries and Aquaculture Science, Barrack Road, Weymouth DT4 8UB, UK.
Glenn WattsEnvironment Agency, Research, Horizon House, Deanery Road, Bristol BS1 5AH, UK.
Andrew WeightmanCardiff University, Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, UK.
Barbara Kasprzyk-HordernUniversity of Bath, Department of Chemistry, 1 South, Bath BA2 7AY, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has put unprecedented pressure on public health resources around the world. From adversity, opportunities have arisen to measure the state and dynamics of human disease at a scale not seen before. In the United Kingdom, the evidence that wastewater could be used to monitor the SARS-CoV-2 virus prompted the development of National wastewater surveillance programmes. The scale and pace of this work has proven to be unique in monitoring of virus dynamics at a national level, demonstrating the importance of wastewater-based epidemiology (WBE) for public health protection. Beyond COVID-19, it can provide additional value for monitoring and informing on a range of biological and chemical markers of human health. A discussion of measurement uncertainty associated with surveillance of wastewater, focusing on lessons-learned from the UK programmes monitoring COVID-19 is presented, showing that sources of uncertainty impacting measurement quality and interpretation of data for public health decision-making, are varied and complex. While some factors remain poorly understood, we present approaches taken by the UK programmes to manage and mitigate the more tractable sources of uncertainty. This work provides a platform to integrate uncertainty management into WBE activities as part of global One Health initiatives beyond the pandemic.

Indexed as

COVID-19PandemicsHumansSARS-CoV-2UncertaintyWastewaterWastewater-Based Epidemiological MonitoringWastewaterHuman pathogensMeasurement variabilityPublic healthUncertainty analysisWastewater-based epidemiology

Identifiers

PMID34655869
PMCPMC8498793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.