Evidence map›Paper›PMID 34655842›Full record

ArticleBioorganic chemistry2021

Profiling sirtuin activity using Copper-free click chemistry.

Alyson M Curry, Ian Cohen, Song Zheng, Jessica Wohlfahrt, Dawanna S White, Dickson Donu, Yana Cen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alyson M CurryDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, United States.
Ian CohenDepartment of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, United States.
Song ZhengDepartment of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, United States.
Jessica WohlfahrtDepartment of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, United States.
Dawanna S WhiteDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, United States.
Dickson DonuDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, United States.
Yana CenDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, United States; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA 23219, United States. Electronic address: ceny2@vcu.edu.
Virginia Commonwealth University · USAlbany College of Pharmacy and Health Sciences · US

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Novel Probes for Sirtuins: A Chemical Biology ApproachR15GM123393 · NIGMS · ALBANY COLLEGE OF PHARMACY · PI HASS, MARTHA A. · 2017 to 2017
$480k
NCATS NIH HHS UL1 TR002649NIGMS NIH HHS R15 GM123393
6 · The paper itself

Abstract

The mammalian sirtuins are a group of posttranslational modification enzymes that remove acyl modifications from lysine residues in an NAD

Indexed as

AnimalsAzidesClick ChemistryEnzyme AssaysFluorescent DyesHumansMolecular ProbesSirtuinsAzidesFluorescent DyesMolecular ProbesSirtuins

Identifiers

PMID34655842
PMCPMC8612980
OpenAlexW3201722867

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.