Evidence map›Paper›PMID 34655805›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022

The Structural Connectome and Internalizing and Externalizing Symptoms at 7 and 13 Years in Individuals Born Very Preterm and Full Term.

Courtney P Gilchrist, Deanne K Thompson, Claire E Kelly, Richard Beare, Christopher Adamson, Thijs Dhollander, Katherine Lee, Karli Treyvaud, Lillian G Matthews, Mary Tolcos and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  11. Vulnerability of the Neonatal Connectome following Postnatal Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Courtney P GilchristSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. Electronic address: courtney.gilchrist@mcri.edu.au.
Deanne K ThompsonVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Claire E KellyVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Turner Institute for Brain and Mental Health, School of Psychological Science, Monash University, Melbourne, Victoria, Australia.
Richard BeareDevelopmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Medicine, Monash University, Melbourne, Victoria, Australia.
Christopher AdamsonDevelopmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Electrical Engineering, University of Melbourne, Melbourne, Victoria, Australia.
Thijs DhollanderDevelopmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Katherine LeeVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
Karli TreyvaudVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Psychology and Counselling, La Trobe University, Melbourne, Victoria, Australia; Newborn Research, Royal Women's Hospital, Melbourne, Victoria, Australia.
Lillian G MatthewsVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia; Turner Institute for Brain and Mental Health, School of Psychological Science, Monash University, Melbourne, Victoria, Australia; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Mary TolcosSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Jeanie L Y CheongVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia; Newborn Research, Royal Women's Hospital, Melbourne, Victoria, Australia.
Terrie E InderVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Lex W DoyleVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia; Newborn Research, Royal Women's Hospital, Melbourne, Victoria, Australia.
Angela CumberlandSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Peter J AndersonVictorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Turner Institute for Brain and Mental Health, School of Psychological Science, Monash University, Melbourne, Victoria, Australia. Electronic address: peter.j.anderson@monash.edu.
Murdoch Children's Research Institute · AUThe University of Melbourne · AUBrigham and Women's Hospital · USRMIT University · AURoyal Women's Hospital · AURoyal Children's Hospital · AU

Funding

Neurobehavioral Impairments in Preterm Children - A Longitudinal MR StudyR01HD058056 · NICHD · WASHINGTON UNIVERSITY · PI INDER, TERRIE E · 2008 to 2011
$1.9M
NICHD NIH HHS R01 HD058056
6 · The paper itself

Abstract

backgroundChildren born very preterm (VP) are at higher risk of emotional and behavioral problems compared with full-term (FT) children. We investigated the neurobiological basis of internalizing and externalizing symptoms in individuals born VP and FT by applying a graph theory approach.

methodsStructural and diffusion magnetic resonance imaging data were combined to generate structural connectomes and calculate measures of network integration and segregation at 7 (VP: 72; FT: 17) and 13 (VP: 125; FT: 44) years. Internalizing and externalizing symptoms were assessed at 7 and 13 years using the Strengths and Difficulties Questionnaire. Linear regression models were used to relate network measures and internalizing and externalizing symptoms concurrently at 7 and 13 years.

resultsLower network integration (characteristic path length and global efficiency) was associated with higher internalizing symptoms in VP and FT children at 7 years, but not at 13 years. The association between network integration (characteristic path length) and externalizing symptoms at 7 years was weaker, but there was some evidence for differential associations between groups, with lower integration in the VP group and higher integration in the FT group associated with higher externalizing symptoms. At 13 years, there was some evidence that associations between network segregation (average clustering coefficient, transitivity, local efficiency) and externalizing symptoms differed between the VP and FT groups, with stronger positive associations in the VP group.

conclusionsThis study provides insights into the neurobiological basis of emotional and behavioral problems after preterm birth, highlighting the role of the structural connectome in internalizing and externalizing symptoms in childhood and adolescence.

Indexed as

ConnectomePremature BirthProblem BehaviorAdolescentChildDiffusion Magnetic Resonance ImagingHumansInfant, Extremely PrematureInfant, NewbornAdolescenceChildhoodConnectivityMagnetic resonance imagingPremature birthPsychopathology

Identifiers

PMID34655805
PMCPMC8995318
OpenAlexW3207674081

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.