ReviewInternational endodontic journal2022
A critical analysis of research methods to study clinical molecular biomarkers in Endodontic research.
Review in International endodontic journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Effects of 660 nm & 808 nm photo-biomodulation on S100A8/A9 in symptomatic pulpitis: a randomized controlled trial.Lasers in medical science · 2026Trial
- Randomised Controlled Trial on the Additive Effect Between Calcium Hydroxide and Sodium Hypochlorite in an Inter-Visit Root Canal Dressing.International endodontic journal · 2026Trial
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels.BMC oral health · 2025Article
- Clinical and imaging aspects associated with persistent apical periodontitis: subsides for the treatment decision-making process.Clinical oral investigations · 2025Article
- The future of endodontic diagnosis: A narrative review focusing on biological markers.JADA foundational science · 2025Review
- Advances in clinical and translational research in endodontics: A comprehensive overview.Brazilian dental journal · 2025Review
- Survival analysis of pulpotomy versus pulpectomy in primary molars with carious pulp exposure: a retrospective cohort study.BMC oral health · 2024Article
- Comparing the accuracy of two machine learning models in detection and classification of periapical lesions using periapical radiographs.Oral radiology · 2024Article
- A Roadmap for the Rational Use of Biomarkers in Oral Disease Screening.Biomolecules · 2024Review
- Systemic Antibiotic Use in Acute Irreversible Pulpitis: Evaluating Clinical Practices and Molecular Insights.International journal of molecular sciences · 2024Review
- Matrix metalloproteinase 9 level changes in gingival crevicular fluid samples of teeth with acute and chronic apical periodontitis.Dental research journal · 2024Article
- Bioactive Endodontic Hydrogels: From Parameters to Personalized Medicine.International journal of molecular sciences · 2023Review
- Present status and future directions-Vital pulp treatment and pulp preservation strategies.International endodontic journal · 2022Review
- A critical analysis of research methods to study clinical molecular biomarkers in Endodontic research.International endodontic journal · 2022Review
- Clinical laboratory diagnostics in dentistry: Application of microbiological methods.Frontiers in oral health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors of this narrative review aimed to address various experimental methods and make recommendations for how research should move forward in the context of studying biomarkers in clinical Endodontic research. The approach adopted is exemplified using two prominent clinical problems, namely (a) the 'reversible' versus 'irreversible' pulpitis conundrum and (b) persistent idiopathic dentoalveolar pain (PIDAP). Pulpitis under deep caries or dentinal cracks is understood from a histological perspective, but clinical assessment tools to indicate irreversibly inflamed aspects of the dental pulp are elusive. PIDAP, on the other hand, is a diagnosis of exclusion; its pathophysiology is complex and not understood sufficiently to avoid unnecessary dental treatments. This review addresses how diagnostic biomarkers could further our understanding of those and other clinical problems, and how issues can be tackled from a methodological point of view. Hence, different methodological approaches to identify suitable diagnostic biomarker(s) or use known biomarkers are presented. The importance of asking a relevant research question, collecting the most suitable fluid and using the ideal collection vehicle for the research question under investigation is discussed based on the defined clinical problems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.