ArticleAging clinical and experimental research2022
Association between systemic inflammation and activities of daily living disability among Chinese elderly individuals: the mediating role of handgrip strength.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Dose-Response Association Between Handgrip Strength and All-Cause Mortality Across Different Levels of Systemic Inflammation.Journal of cachexia, sarcopenia and muscle · 2026Article
- Independent and joint associations of depressive symptoms and social isolation on trajectories of functional disability among middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2026Article
- A Body Shape Index mediates the associations of geriatric nutritional risk index with activities of daily living disability in an older rural population in Guangxi, China.Frontiers in public health · 2026Article
- Article
- Cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning among people aged 50 years and older: evidence from two longitudinal cohort studies.Archives of public health = Archives belges de sante publique · 2025Article
- Effect of dentition status on perceived mobility limitation among older Brazilian adults: a cohort study.Brazilian oral research · 2025Article
- Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients.Annals of geriatric medicine and research · 2024Article
- Long and short sleep durations can affect cognitive function in older adults through the chain mediation effect of ADL and depression: evidence from CHARLS2018.Aging clinical and experimental research · 2024Article
- Associations of handgrip weakness and asymmetry with new-onset stroke in Chinese middle-aged and older adults: a cohort study.Frontiers in public health · 2023Article
- Comorbid depression and obesity, and its transition on the risk of functional disability among middle-aged and older Chinese: a cohort study.BMC geriatrics · 2022Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAging is accompanied by chronic low-grade inflammation (inflammaging), which is a risk factor for low handgrip strength (HGS) and activities of daily living (ADL) disability.
aimsTo explore the association between C-reactive protein (CRP) and ADL disability in Chinese elderly individuals and to further evaluate the mediating role of HGS in this association.
methodsWe used data from the China Health and Retirement Longitudinal Study (CHARLS) that were collected in 2015. A total of 3601 elderly individuals aged ≥ 60 years were included. Baron and Kenny's causal steps method was used to explore the possible mediating role of HGS in the associations between CRP and ADL disability. Karlson-Holm-Breen method was further applied to decompose total effect into direct effect and indirect effect via HGS. Subgroup analysis was conducted by sex and age.
resultsA high level of CRP (≥ 3 mg/L) was significantly associated with ADL disability after adjustment for covariates (OR = 1.50, 95% CI = 1.17-1.94). After introducing HGS into the model, the risk estimate was reduced but still significant (OR = 1.40, 95% CI = 1.08-1.81). The proportional mediation through HGS was 14.71%. Similar results were observed in both sexes and in participants aged < 70 years.
conclusionCRP was positively associated with the risk of ADL disability in Chinese elderly individuals, and this association was mediated by HGS. Improving muscle strength in combination with anti-inflammatory treatment may have a beneficial effect to maintain ADL ability. Further randomized controlled trials on this topic are necessary.
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