Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022
Quality of life in adults with autism spectrum disorder: influence of age, sex, and a controlled, randomized mindfulness-based stress reduction pilot intervention.
Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04017793 (The Neural Changes Associated With a Mindfulness Intervention for Adults With Autism Spectrum Disorder), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Neural Changes Associated With a Mindfulness Intervention for Adults With Autism Spectrum Disorder
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The Biochemical Effects of Resveratrol Intake on the Neurobehavioral Aspects of Autism Spectrum Disorders: A Systematic Review.Central nervous system agents in medicinal chemistry · 2026Pooled it
- Mindfulness to improve the mental health of university students. A systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Distinct and shared therapeutic neural mechanisms of mindfulness-based and social support stress reduction groups in adults with autism spectrum disorder.Journal of psychiatry & neuroscience : JPNTrial
- Quality-of-life assessment in autistic adults with lower support needs: gaps and emerging challenges.Frontiers in psychiatry · 2026Review
- Mental Health as a Key Mediator for Outcomes in Postsecondary Education, Employment, and Everyday Living in Autistic Adults.Autism in adulthood · 2025Article
- Barriers to healthcare predict reduced health-related quality of life in autistic adults without intellectual disability.Autism : the international journal of research and practice · 2025Article
- Autism Spectrum Disorder in adults: an integrative review about strategies for promotion and maintenance of quality of life.Sao Paulo medical journal = Revista paulista de medicina · 2025Review
- Mindfulness-Based Interventions for People with Autism Spectrum Disorder: A Systematic Literature Review.Brain sciences · 2024Review
- Mental Health and Quality of Life in Chronic Kidney Disease Patients with Mild-to-Moderate Depression: A Retrospective Cohort Study of Mindfulness-Based Stress Reduction Therapy.Actas espanolas de psiquiatria · 2024Article
- Mindfulness-based stress reduction for autistic adults: A feasibility study in an outpatient context.Autism : the international journal of research and practice · 2024Article
- Self-Report Measurement of Well-Being in Autistic Adults: Psychometric Properties of the PERMA Profiler.Autism in adulthood · 2023Article
- Phenotypically driven subgroups of ASD display distinct metabolomic profiles.Brain, behavior, and immunity · 2023Article
- Toward patient-centered treatment goals for duchenne muscular dystrophy: insights from the "Your Voice" study.Orphanet journal of rare diseases · 2023Article
- Adolescence internalizing problems as a mediator between autism diagnosis in childhood and quality of life in emerging adults with and without autism: a 10-year longitudinal study.BMC psychiatry · 2023Article
- Quality of Life, Neurosensory Disorders and Co-Occurring Medical Conditions in Individuals on the Spectrum, with a Special Focus on Females Diagnosed with Autism: A Systematic Review.Journal of clinical medicine · 2023Review
- Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington's disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross-sectional findings.Autism research : official journal of the International Society for Autism Research · 2022Article
- Virtual group-based mindfulness program for autistic women: A feasibility study.Women's health (London, England)Article
- Fit-for-purpose Psychological Interventions to Support the Well-Being of Autistic Adults: A Systematic Review.Autism & developmental language impairmentsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeAdults with autism spectrum disorder (ASD) consistently report worse functional health and well-being, compared to neurotypical (NT) peers. In a series of studies, we aimed to elucidated the effects of sex, age, and their interaction on health-related quality of life (HRQoL) and evaluated the effectiveness of mindfulness-based stress reduction (MBSR) for improving health-, disability-, and autism-related QoL, with possible sex and age outcome moderators, in adults with ASD.
methodsStudy 1 used the 36-Item Short Form Survey to compare mental and physical HRQoL composite scores in adults with ASD (n = 67) and matched NT adults (n = 66). Study 2 was a randomized pilot evaluation of the effect of MBSR, compared to an active control intervention with social support and relaxation education (support/education; n = 56), on the World Health Organization QoL BREF, Disability, and Autism-Specific scales in adults with ASD.
resultsIn Study 1, we replicated findings that mental HRQoL is worse in both men and women with ASD, compared to NT counterparts, but physical HRQoL is only worse in women with ASD. We present novel findings that older age is associated with better mental HRQoL in women with ASD only. In Study 2, MBSR improved disability-related QoL in adults with ASD over and above the support/education intervention, but both interventions improved mental HRQoL. Lastly, both interventions were more effective for HRQoL improvements in women with ASD.
conclusionFindings encourage precision medicine approaches tailored to age and sex groups for best HRQoL outcomes in adults with ASD. CLINICALTRIALS: gov Identifier: NCT04017793.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.