Evidence map›Paper›PMID 34655304›Full record

Trial reportWorld journal of urology2022

'Pee'BuSt Trial: A single-centre prospective randomized study comparing functional and anatomic outcomes after augmentation  urethroplasty with penile skin graft versus buccal mucosa graft for anterior urethral stricture disease.

Shantanu Tyagi, Kalpesh Mahesh Parmar, Shrawan Kumar Singh, Anuj Sharma, Mukesh Shukla, Aditya Prakash Sharma, Sudheer Kumar Devana, Gopal Sharma, Santosh Kumar, Arup Kumar Mandal

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Advances in urethroplasty.Medical journal, Armed Forces India · 2023
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shantanu TyagiDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Kalpesh Mahesh ParmarDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012. kalpesh010385@gmail.com.ORCID http://orcid.org/0000-0003-3891-4089
Shrawan Kumar SinghDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Anuj SharmaDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Mukesh ShuklaDepartment of Community Medicine, Veer Chandra Singh Garhwali Government Institute of Medical Science & Research, Srinagar, Uttarakhand, India.
Aditya Prakash SharmaDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Sudheer Kumar DevanaDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Gopal SharmaDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Santosh KumarDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Arup Kumar MandalDepartment of Urology, Post Graduate Institute of Medical Education and Research (PGIMER), Advanced Urology Ward, Level 2, B-Block, Chandigarh, Punjab, India, 160012.
Post Graduate Institute of Medical Education and Research · INGovernment Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the surgical outcomes of augmentation urethroplasty (AU) using penile skin graft (PSG) compared to buccal mucosa graft (BMG) in anterior urethral stricture disease.

methodBetween January 2018 and January 2019, 100 patients with anterior urethral stricture planned for AU were randomized into PSG or BMG arms (CTRI/2018/07/015028). Anatomic and functional variables were compared pre-operatively and post-operatively. Primary outcome was success rate at 18 months and it was defined if any of the three criteria were met, i.e. either maximum urinary flow (Qmax) > 15 ml/s or urethral calibration of 16 French or ability to traverse the repair with 17 French cystoscope. Secondary outcomes were functional parameters such as International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF) Score, Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EJD), and Urethral Stricture Surgery-Patient Related Outcome Measure (USS-PROM).

resultsPre-operative variables were comparable between both the arms. Median duration of follow-up was 22 months (18-24 months). At 18 months, the success rates of AU with PSG and BMG were comparable (89% v/s 91%; p = 0.70, 95% CI-0.33 to 5.21). The improvements in Qmax (p = 0.06), IPSS (p = 0.43) and USS-PROM (p = 0.49) were comparable between the two arms. There was no statistically significant difference in the IIEF-Erectile domain (p = 0.07), IIEF-Orgasmic domain (p = 0.11) and MSHQ-EJD (p = 0.20) following AU at 18 months. Clavien-Dindo grade I complications were 12.7% in PSG and 16.7% in BMG.

conclusionThis study provides level 1 evidence of no statistical significant difference in outcomes of AU using BMG or PSG.

Indexed as

Urethral StrictureHumansMaleMouth MucosaProspective StudiesSkin TransplantationTreatment OutcomeUrethraUrologic Surgical Procedures, MaleAugmentation urethroplastyBuccal mucosa graftLUTSPenile skin graftPROMSUrethral stricture

Identifiers

PMID34655304
PMCPMC8520101
OpenAlexW3205770103

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.