ArticleMagnetic resonance in medicine2022
Off-resonance saturation as an MRI method to quantify mineral- iron in the post-mortem brain.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review).International journal of molecular medicine · 2026Review
- In-depth magnetometry and EPR analysis of the spin structure of human-liver ferritin: from DC to 9 GHz.Physical chemistry chemical physics : PCCP · 2023Article
- Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Off-resonance saturation as an MRI method to quantify mineral- iron in the post-mortem brain.Magnetic resonance in medicine · 2022Article
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9 authors.
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Abstract
purposeTo employ an off-resonance saturation method to measure the mineral-iron pool in the postmortem brain, which is an endogenous contrast agent that can give information on cellular iron status.
methodsAn off-resonance saturation acquisition protocol was implemented on a 7 Tesla preclinical scanner, and the contrast maps were fitted to an established analytical model. The method was validated by correlation and Bland-Altman analysis on a ferritin-containing phantom. Mineral-iron maps were obtained from postmortem tissue of patients with neurological diseases characterized by brain iron accumulation, that is, Alzheimer disease, Huntington disease, and aceruloplasminemia, and validated with histology. Transverse relaxation rate and magnetic susceptibility values were used for comparison.
resultsIn postmortem tissue, the mineral-iron contrast colocalizes with histological iron staining in all the cases. Iron concentrations obtained via the off-resonance saturation method are in agreement with literature.
conclusionsOff-resonance saturation is an effective way to detect iron in gray matter structures and partially mitigate for the presence of myelin. If a reference region with little iron is available in the tissue, the method can produce quantitative iron maps. This method is applicable in the study of diseases characterized by brain iron accumulation and can complement existing iron-sensitive parametric methods.
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