Evidence map›Paper›PMID 34655015›Full record

ArticleMolecular biology reports2021

Investigation of the hepatic mTOR/S6K1/SREBP1 signalling pathway in rats at different ages: from neonates to adults.

Meltem Yalçın, Mehtap Kaçar

Abstract read
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In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. PMFrontiers in endocrinology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Meltem YalçınDepartment of Physiology, Faculty of Medicine, Yeditepe University, İnönü District, Kayışdağı Street, August 26 Campus, Atasehir, İstanbul, Turkey, 34755.ORCID http://orcid.org/0000-0001-8474-6464
Mehtap KaçarDepartment of Physiology, Faculty of Medicine, Yeditepe University, İnönü District, Kayışdağı Street, August 26 Campus, Atasehir, İstanbul, Turkey, 34755. mehtap.kacar@yeditepe.edu.tr.ORCID http://orcid.org/0000-0002-1572-4787
Yeditepe University · TR

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 119S221
6 · The paper itself

Abstract

backgroundDysfunctions in the lipogenic process controlled by the hepatic mTOR/S6K1/SREBP-1c signaling pathway may contribute to the pathogenesis of various chronic diseases. In the present study, we aimed to determine age-related changes in the mTOR/S6K1/SREBP1 pathway in rat liver tissues. METHODS AND

resultsWe performed Western Blot analysis to determine age-related changes in the mTOR/S6K1/SREBP1 pathway in Sprague Dawley male rats liver tissues of six different age groups representing neonatal, infant, weaning, puberty, young adult, adult life periods, and Oil Red O staining to evaluate age-related lipid accumulation. We observed an increase in Akt and p-Akt levels with age in compared to the 0-day-old group. Total mTOR and SREBP1 expression increased from the 0-day-old to the 28-day-old group but decreased in the following age groups. p-mTOR and p-S6K1 levels in the 0-day-old group were higher than the other groups. S6K1 expression was lowest in the 0-day-old group and showed changes among the age groups. Lipid accumulation was seen in liver sections taken from the 12-month-old group. mTOR/S6K1/SREBP1 pathway expression showed changes with age during the neonatal-adult life cycle stages in rat liver tissues.

conclusionWe suggest that understanding the molecular mechanisms age-related changes of lipogenesis function is necessary to contribute to the development of therapeutic approaches.

Indexed as

LipogenesisSignal TransductionAge FactorsAnimalsGene Expression RegulationLiverMaleRatsRats, Sprague-DawleyRibosomal Protein S6 KinasesSterol Regulatory Element Binding Protein 1TOR Serine-Threonine KinasesmTOR protein, ratRibosomal Protein S6 KinasesRps6kb1 protein, ratSrebf1 protein, ratSterol Regulatory Element Binding Protein 1TOR Serine-Threonine KinasesAgeLipogenesisLivermTORSREBP1

Identifiers

PMID34655015
OpenAlexW3207824202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.