AL Lambda Amyloidosis Activates Acute Liver Failure in the Absence of Plasma Cell Dyscrasia.

Nilofar Najafian, Andrew T Weber, Jonathan E Zuckerman, Sarah Zhang, Sammy Saab, Gina Choi

Abstract readCase Reports

In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 90% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nilofar NajafianDepartments of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Andrew T WeberDepartments of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Jonathan E ZuckermanDepartments of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Sarah ZhangDepartments of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Sammy SaabDepartments of Medicine, University of California at Los Angeles, Los Angeles, CA, USA. SSaab@mednet.ucla.edu.

Gina ChoiDepartments of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A patient with systemic amyloidosis developed portal hypertension, acute liver failure and multiorgan dysfunction. Extensive testing was unrevealing for paraproteinemia, plasma cell dyscrasia, infectious, or inflammatory conditions. He was transferred to our institution for orthotopic liver transplant evaluation but was ultimately declined given clinical instability and dysautonomia. Post-mortem evaluation revealed extensive amyloid deposition in multiple organs determined to be AL-lambda amyloidosis.

Indexed as

Amyloidosis, FamilialAscitesLiverLiver Failure, AcutePlaque, AmyloidClinical DeteriorationFatal OutcomeHepatic EncephalopathyHumansImage-Guided BiopsyImmunoglobulin lambda-ChainsIntestinal ObstructionLiver Function TestsMaleMiddle AgedParacentesisImmunoglobulin lambda-ChainsAcute liver failureAmyloidPortal hypertension

Identifiers

PMID34655012

DOI10.1007/s10620-021-07253-2

OpenAlexW3207937093

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.