Evidence map›Paper›PMID 34655011›Full record

ArticleInflammation2022

Dietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice.

Paige Fletcher, Raymond F Hamilton, Joseph F Rhoderick, Britten Postma, Mary Buford, James J Pestka, Andrij Holian

Open access · greenAbstract read
In one paragraph

Article in Inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Paige FletcherDepartment of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, MT, USA. paige.fletcher@umontana.edu.ORCID http://orcid.org/0000-0001-6860-305X
Raymond F HamiltonDepartment of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, MT, USA.
Joseph F RhoderickDepartment of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, MT, USA.
Britten PostmaDepartment of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, MT, USA.
Mary BufordDepartment of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, MT, USA.
James J PestkaDepartment of Food Science and Human Nutrition, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.
Andrij HolianDepartment of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, MT, USA.
Center for Environmental Health · USMichigan State University · US

Funding

Molecular Histology and Fluorescent ImagingP30GM103338 · NIGMS · UNIVERSITY OF MONTANA · PI ROBERTS, KEVAN · 2013 to 2017
$5.6M
Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.R01ES027353 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2017 to 2026
$4.8M
Dietary DHA attenuation of nanoparticle inflammationR01ES023209 · NIEHS · UNIVERSITY OF MONTANA · PI HOLIAN, ANDRIJ · 2014 to 2018
$2.8M
Investigation of docosahexaenoic acid as a treatment for particle-induced inflammationF31ES028100 · NIEHS · UNIVERSITY OF MONTANA · PI FLETCHER, PAIGE · 2018 to 2020
$109k
NIEHS NIH HHS F31 ES028100NIEHS NIH HHS R01 ES023209NIEHS NIH HHS R01 ES027353NIGMS NIH HHS P30 GM103338
6 · The paper itself

Abstract

Acute and chronic inflammation are vital contributing factors to pulmonary diseases which can be triggered by exposure to occupational and man-made particles; however, there are no established treatments. One potential treatment shown to have anti-inflammatory capabilities is the dietary supplement docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid found in fish oil. DHA's anti-inflammatory mechanisms are unclear for particle-induced inflammation; therefore, this study evaluated DHA as a prophylactic treatment for semi-acute and chronic particle-induced inflammation in vivo. Balb/c mice were fed a control or 1% DHA diet and exposed to dispersion media, an inflammatory multi-walled carbon nanotube (MWCNT), or crystalline silica (SiO

Indexed as

Docosahexaenoic AcidsPneumoniaAnimalsDietHumansInflammationMiceMice, Inbred BALB CSilicon DioxideDocosahexaenoic AcidsSilicon Dioxidealveolar macrophagecrystalline silicamacrophage phenotypemulti-walled carbon nanotubephagolysosomal membrane damagepulmonary inflammation

Identifiers

PMID34655011
PMCPMC8957518
OpenAlexW3207217418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.