Evidence map›Paper›PMID 34654960›Full record

ReviewNeuroradiology2022

Edited magnetic resonance spectroscopy in the neonatal brain.

Yulu Song, Peter J Lally, Maria Yanez Lopez, Georg Oeltzschner, Mary Beth Nebel, Borjan Gagoski, Steven Kecskemeti, Steve C N Hui, Helge J Zöllner, Deepika Shukla and 9 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

Yulu SongRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter J LallyDepartment of Brain Sciences, Imperial College London, London, UK.
Maria Yanez LopezCenter for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mary Beth NebelCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, 21205, USA.
Borjan GagoskiDepartment of Radiology, Division of Neuroradiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Steven KecskemetiWaisman Center, University of WI-Madison, Madison, WI, 53705, USA.
Steve C N HuiRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Deepika ShuklaCentre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
Tomoki ArichiCenter for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Enrico De VitaCenter for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Vivek YedavalliDivision of Neuroradiology, Park 367G, The Johns Hopkins University School of Medicine, 600 N. Wolfe St. B-112 D, Baltimore, MD, 21287, USA.
Sudhin ThayyilCentre for Perinatal Neuroscience, Department of Brain Sciences, Imperial College London, London, UK.
Daniele FallinWendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University, Baltimore, USA.
Douglas C DeanWaisman Center, University of WI-Madison, Madison, WI, 53705, USA.
P Ellen GrantDepartment of Radiology, Division of Neuroradiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jessica L WisnowskiChildren's Hospital Los Angeles, Los Angeles, CA, 90027, USA.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. raee2@jhu.edu.
Imperial College London · GBJohns Hopkins University · USKennedy Krieger Institute · USKing's College London · GBUniversity of Wisconsin–Madison · USBoston Children's Hospital · USCenter for Autism and Related Disorders · USChildren's Hospital of Los Angeles · USHarvard University · US

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Somatosensory Inhibitory Dysfunction in Autism Spectrum Disorder.R01MH106564 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2016 to 2020
$2.5M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
Validating MRS lipids as biomarkers of brain injury in neonates with hypoxic-ischemic encephalopathyK23HD099309 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WISNOWSKI, JESSICA L · 2019 to 2023
$693k
HEALthy ORCHARD: Developing plans for a Baltimore site of the HEALthy BCD studyR34DA050292 · NIDA · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE · 2019 to 2019
$567k
Measuring Altered Glutathione in Children with Autism Spectrum DisorderR21HD100869 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2020 to 2021
$463k
Dysfunction of Sensory Inhibition in AutismR21MH098228 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2013 to 2014
$460k
action medical research GN 2728Medical Research Council MR/N026063/1Medical Research Council MR/P008712/1Medical Research Council MR/V 036874/1Medical Research Council MR/V036874/1NIA NIH HHS K99 AG062230NIA NIH HHS R00 AG062230NIBIB NIH HHS P41 EB015909NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NICHD NIH HHS K23 HD099309NICHD NIH HHS P50 HD103538NICHD NIH HHS P50 HD105351NICHD NIH HHS R21 HD100869NIDA NIH HHS 1R34DA050292-01NIDA NIH HHS R34 DA050292NIH HHS K23 HD 099309NIH HHS P41 EB 031771NIH HHS R00 AG 062230NIH HHS R01 EB016089NIH HHS R01 EB 023963NIH HHS R21 HD 100869NIMH NIH HHS R01 MH106564NIMH NIH HHS R21 MH098228wellcome engineering and physical sciences research countil WT 203148/Z/16/ZWellcome Trust
6 · The paper itself

Abstract

J-difference-edited spectroscopy is a valuable approach for the detection of low-concentration metabolites with magnetic resonance spectroscopy (MRS). Currently, few edited MRS studies are performed in neonates due to suboptimal signal-to-noise ratio, relatively long acquisition times, and vulnerability to motion artifacts. Nonetheless, the technique presents an exciting opportunity in pediatric imaging research to study rapid maturational changes of neurotransmitter systems and other metabolic systems in early postnatal life. Studying these metabolic processes is vital to understanding the widespread and rapid structural and functional changes that occur in the first years of life. The overarching goal of this review is to provide an introduction to edited MRS for neonates, including the current state-of-the-art in editing methods and editable metabolites, as well as to review the current literature applying edited MRS to the neonatal brain. Existing challenges and future opportunities, including the lack of age-specific reference data, are also discussed.

Indexed as

Braingamma-Aminobutyric AcidArtifactsChildHumansInfant, NewbornMagnetic Resonance ImagingMagnetic Resonance Spectroscopygamma-Aminobutyric AcidEdited MRSJ-difference editingLow-concentration metabolitesNeonatal brainRelaxation time

Identifiers

PMID34654960
PMCPMC8887832
OpenAlexW3207702460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.