Evidence map›Paper›PMID 34654900›Full record

ArticleNature biomedical engineering2021

Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds.

Viveka Kalidasan, Xin Yang, Ze Xiong, Renee R Li, Haicheng Yao, Hareesh Godaba, Sybil Obuobi, Priti Singh, Xin Guan, Xi Tian and 12 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 122 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 3 countries.

Viveka Kalidasan *Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore. viveka_k@nus.edu.sg.ORCID http://orcid.org/0000-0001-6890-2527
Xin Yang *Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.
Ze Xiong *Department of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore. elexio@nus.edu.sg.ORCID http://orcid.org/0000-0003-4620-6066
Renee R LiCardiovascular Research Institute, National University Heart Centre, Singapore, Singapore.
Haicheng YaoDepartment of Materials Science and Engineering, National University of Singapore, Singapore, Singapore.
Hareesh GodabaDepartment of Materials Science and Engineering, National University of Singapore, Singapore, Singapore.
Sybil ObuobiDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2905-581X
Priti SinghFaculty of Dentistry, National University of Singapore, Singapore, Singapore.
Xin GuanDepartment of Materials Science and Engineering, National University of Singapore, Singapore, Singapore.
Xi TianDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0003-1633-1210
Selman A KurtDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4549-0774
Zhipeng LiDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-8139-2522
Devika MukherjeeDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
Ravisankar RajarethinamInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9249-7840
Choon Seng ChongDepartment of Surgery, National University Hospital, Singapore, Singapore.ORCID http://orcid.org/0000-0003-0669-7307
Jiong-Wei WangCardiovascular Research Institute, National University Heart Centre, Singapore, Singapore.ORCID http://orcid.org/0000-0001-7986-6082
Pui Lai Rachel EeDepartment of Pharmacy, National University of Singapore, Singapore, Singapore.
Weiqiang LokeFaculty of Dentistry, National University of Singapore, Singapore, Singapore.
Benjamin C K TeeInstitute for Health Innovation and Technology, National University of Singapore, Singapore, Singapore.
Jianyong OuyangDepartment of Materials Science and Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9901-0177
Christopher J CharlesCardiovascular Research Institute, National University Heart Centre, Singapore, Singapore.
John S HoDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore, Singapore. johnho@nus.edu.sg.ORCID http://orcid.org/0000-0002-9458-9033
National University of Singapore · SGAgency for Science, Technology and Research · SGNational University Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring surgical wounds post-operatively is necessary to prevent infection, dehiscence and other complications. However, the monitoring of deep surgical sites is typically limited to indirect observations or to costly radiological investigations that often fail to detect complications before they become severe. Bioelectronic sensors could provide accurate and continuous monitoring from within the body, but the form factors of existing devices are not amenable to integration with sensitive wound tissues and to wireless data transmission. Here we show that multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites. We show in live pigs that the sutures can monitor wound integrity, gastric leakage and tissue micromotions, and in rodents that the healing outcomes are equivalent to those of medical-grade sutures. Battery-free wirelessly operated bioelectronic sutures may facilitate post-surgical monitoring in a wide range of interventions.

Indexed as

Surgical WoundSurgical Wound DehiscenceAnimalsSuturesSuture TechniquesSwineWound Healing

Identifiers

PMID34654900
OpenAlexW3206148902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.