Evidence map›Paper›PMID 34654894›Full record

ArticleScientific reports2021

Dried blood sample analysis by antibody array across the total testing process.

Kelly Whittaker, Ying-Qing Mao, Yongping Lin, Huihua Zhang, Siwei Zhu, Hannah Peck, Ruo-Pan Huang

Open access · goldAbstract readValidation Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Dried Spot Paradigm: Problems and Prospects in Proteomics.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kelly Whittaker *RayBiotech Life, 3607 Parkway Lane, Peachtree Corners, GA, 30092, USA.
Ying-Qing Mao *RayBiotech Life, 3607 Parkway Lane, Peachtree Corners, GA, 30092, USA.
Yongping Lin *Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510000, Guangdong, China.
Huihua ZhangRayBiotech Guangzhou, 79 Ruihe Road, Huangpu district, Guangzhou, 510630, Guangdong, China.
Siwei ZhuRayBiotech Guangzhou, 79 Ruihe Road, Huangpu district, Guangzhou, 510630, Guangdong, China.
Hannah PeckRayBiotech Life, 3607 Parkway Lane, Peachtree Corners, GA, 30092, USA.
Ruo-Pan HuangRayBiotech Life, 3607 Parkway Lane, Peachtree Corners, GA, 30092, USA. rhuang@raybiotech.com.
RayBiotech (China) · CNRayBiotech (United States) · USGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dried blood samples (DBSs) have many advantages; yet, impediments have limited the clinical utilization of DBSs. We developed a novel volumetric sampling device that collects a precise volume of blood, which overcomes the heterogeneity and hematocrit issues commonly encountered in a traditional DBS card collection as well as allowing for more efficient extraction and processing procedures and thus, more efficient quantitation, by using the entire sample. We also provided a thorough procedure validation using this volumetric DBS collection device with an established quantitative proteomics analysis method, and then analyzed 1000 proteins using this approach in DBSs concomitantly with serum for future consideration of utility in clinical applications. Our data provide a first step in the establishment of a DBS database for the broad application of this sample type for widespread use in clinical proteomic and other analyses applications.

Indexed as

Microarray AnalysisAdultAgedDried Blood Spot TestingFemaleHumansImmunoassayMaleMiddle AgedProteomics

Identifiers

PMID34654894
PMCPMC8521592
OpenAlexW3207838239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.