ArticleScientific reports2021
Identification and characterization of CYPs induced in the Drosophila antenna by exposure to a plant odorant.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Prolonged Exposure to Plant Volatiles does not Significantly Affect Pban Expression and Mating Behavior in Diamondback Moth [Plutella Xylostella (Lepidoptera: Plutellidae)].Journal of chemical ecology · 2024Article
- Odorant receptor co-receptors affect expression of tuning receptors inFrontiers in cellular neuroscience · 2024Article
- Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages.BMC plant biology · 2023Article
- The rich non-coding RNA landscape of the Drosophila antenna.Cell reports · 2023Article
- Antennal transcriptomic analysis of carboxylesterases and glutathione S-transferases associated with odorant degradation in the tea gray geometrid,Frontiers in physiology · 2023Article
- Review
- Article
- Antennae-abundant expression of candidate cytochrome P450 genes associated with odorant degradation in the asian citrus psyllid,Frontiers in physiology · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Members of the cytochrome p450 (CYP) enzyme family are abundantly expressed in insect olfactory tissues, where they are thought to act as Odorant Degrading Enzymes (ODEs). However, their contribution to olfactory signaling in vivo is poorly understood. This is due in part to the challenge of identifying which of the dozens of antennal-expressed CYPs might inactivate a given odorant. Here, we tested a high-throughput deorphanization strategy in Drosophila to identify CYPs that are transcriptionally induced by exposure to odorants. We discovered three CYPs selectively upregulated by geranyl acetate using transcriptional profiling. Although these CYPs are broadly expressed in the antenna in non-neuronal cells, electrophysiological recordings from CYP mutants did not reveal any changes in olfactory neuron responses to this odorant. Neurons were desensitized by pre-exposing flies to the odorant, but this effect was similar in CYP mutants. Together, our data suggest that the induction of a CYP gene by an odorant does not necessarily indicate a role for that CYP in neuronal responses to that odorant. We go on to show that some CYPs have highly restricted expression patterns in the antenna, and suggest that such CYPs may be useful candidates for further studies on olfactory CYP function.
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