Evidence map›Paper›PMID 34654743›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents.

He Wei, Agata Wiśniowska, Jingxuan Fan, Peter Harvey, Yuanyuan Li, Victoria Wu, Eric C Hansen, Juanye Zhang, Michael G Kaul, Abigail M Frey and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  14. Review
  15. Iron oxide nanoparticles as positive TScientific reports · 2023
    Article
  16. Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles viaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

He WeiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Agata WiśniowskaHarvard-Massachusetts Institute of Technology Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Jingxuan FanDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Peter HarveyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Yuanyuan LiDepartment of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, NY 11794.
Victoria WuDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Eric C HansenDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
Juanye ZhangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
Michael G KaulDepartment of Diagnostic and Interventional Radiology and Nuclear Medicine, Center for Radiology and Endoscopy, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Abigail M FreyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Gerhard AdamDepartment of Diagnostic and Interventional Radiology and Nuclear Medicine, Center for Radiology and Endoscopy, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Anatoly I FrenkelDepartment of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, NY 11794.
Moungi G BawendiDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; mgb@mit.edu jasanoff@mit.edu.
Alan JasanoffDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; mgb@mit.edu jasanoff@mit.edu.ORCID 0000-0002-2834-6359

Funding

Advanced Multimodal Neuroimaging Training GrantR90DA023427 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2006 to 2015
$2.8M
Molecular imaging of dopaminergic signaling in rodent brainR01DA038642 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2015 to 2019
$2.8M
Intracellular calcium sensing with molecular fMRIUF1NS107712 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2018 to 2018
$1.4M
Toward functional molecular neuroimaging using vasoactive probes in human subjects.R24MH109081 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2015 to 2017
$1.3M
NIDA NIH HHS R01 DA038642NIDA NIH HHS R90 DA023427NIMH NIH HHS R24 MH109081NINDS NIH HHS UF1 NS107712
6 · The paper itself

Abstract

Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in

Indexed as

AnimalsBlood-Brain BarrierContrast MediaMagnetic Iron Oxide NanoparticlesMagnetic Resonance ImagingParticle SizePermeabilityRatsContrast Mediabrainiron oxide nanoparticlemagnetic resonance imagingmolecular imaging

Identifiers

PMID34654743
PMCPMC8545496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.