Evidence map›Paper›PMID 34654676›Full record

ReviewJournal of cardiovascular computed tomography

The evolving role of coronary computed tomography in understanding sex differences in coronary atherosclerosis.

Keva Garg, Toral R Patel, Arjun Kanwal, Todd C Villines, Niti R Aggarwal, Khurram Nasir, Roger S Blumenthal, Michael J Blaha, Pamela S Douglas, Leslee J Shaw and 1 more

Abstract readReview
In one paragraph

Review in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Role of Cardiac Computed Tomography Angiography in Risk Stratification for Coronary Artery Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Review
  7. Update on sex specific risk factors in cardiovascular disease.Frontiers in cardiovascular medicine · 2024
    Review
  8. Article
  9. Gender Medicine in Clinical Radiology Practice.Journal of personalized medicine · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Keva GargDivision of Cardiology, The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Toral R PatelDepartment of Cardiovascular Disease, University of Virginia, Charlottesville, VA, USA.
Arjun KanwalMedstar Union Memorial Hospital, Baltimore, MD, USA.
Todd C VillinesDepartment of Cardiovascular Disease, University of Virginia, Charlottesville, VA, USA.
Niti R AggarwalDepartment of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USA.
Khurram NasirCenter for Outcomes Research, Division of Cardiology, Houston Methodist, Houston, TX, USA.
Roger S BlumenthalDivision of Cardiology, The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael J BlahaDivision of Cardiology, The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pamela S DouglasDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Leslee J ShawDepartment of Population Health Science, Blavatnik Women's Health Research Institute, Mount Sinai School of Medicine, NY, USA.
Garima SharmaDivision of Cardiology, The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: gsharma8@jhmi.edu.

Funding

Training in Cardiovascular Imaging ResearchT32EB003841 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jonathan R Lindner · 2004 to 2026
$4.4M
NIBIB NIH HHS T32 EB003841
6 · The paper itself

Abstract

Our understanding of sex differences in subclinical atherosclerosis and plaque composition and characteristics have greatly improved with the use of coronary computed tomography (CCTA) over the past years. CCTA has emerged as an important frontline diagnostic test for women, especially as we continue to understand the impact of non-obstructive atherosclerosis as well as diffuse, high risk plaque as precursors of acute cardiac events in women. Based on its ability to identify complex plaque morphology such as low attenuation plaque, high risk non calcified plaque, positive remodeling, fibrous cap, CCTA can be used to assess plaque characteristics. CCTA can avoid false positive of other imaging studies, if included earlier in assessment of ischemic symptoms. In the contemporary clinical setting, CCTA will prove useful in further understanding and managing cardiovascular disease in women and those without traditional obstructive coronary disease.

Indexed as

Coronary Artery DiseasePlaque, AtheroscleroticComputed Tomography AngiographyCoronary AngiographyFemaleHumansMalePredictive Value of TestsSex CharacteristicsTomography, X-Ray ComputedAnd cardiac computed tomographyAtherosclerosisCardiovascular diseaseIschemic heart diseaseSexSex disparitiesWomen

Identifiers

PMID34654676
PMCPMC9358989

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.