Evidence map›Paper›PMID 34654528›Full record

SynthesisMaturitas2021

Sexual violence and cardiovascular disease risk: A systematic review and meta-analysis.

Karen P Jakubowski, Vanessa Murray, Natalie Stokes, Rebecca C Thurston

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Maturitas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Addressing sexual violence: A FIGO Committee on Women Facing Crises consensus statement.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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  11. Intimate partner violence and cognitive functioning - toward quantifying dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen P JakubowskiDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: jakubowskik@upmc.edu.
Vanessa MurrayDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: Murray.Vanessa@medstudent.pitt.edu.
Natalie StokesHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: stokesnr@upmc.edu.
Rebecca C ThurstonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: thurstonrc@upmc.edu.

Funding

CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
CLINICAL RESEARCH TRAINING FOR PSYCHOLOGISTST32MH018269 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHELE D LEVINE · 1986 to 2026
$6.3M
Menopausal Vasomotor Symptoms and Brain Aging in WomenRF1AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2016 to 2019
$4.1M
Menopausal Vasomotor Symptoms and Brain Aging in WomenR01AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2021 to 2025
$3.8M
Mechanisms linking hot flashes to cardiovascular riskR01HL105647 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2011 to 2015
$3.2M
Interdisciplinary Mentoring and Research in Womens Cardiovascular HealthK24HL123565 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2014 to 2023
$1.0M
NHLBI NIH HHS K24 HL123565NHLBI NIH HHS R01 HL105647NHLBI NIH HHS T32 HL007560NIA NIH HHS R01 AG053504NIA NIH HHS RF1 AG053504NIMH NIH HHS T32 MH018269
6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) is a leading cause of death among adults. Over 35% of women worldwide report lifetime exposure to sexual violence. While psychosocial factors broadly have been linked to CVD risk, it is unclear if a history of sexual violence is associated with increased risk for CVD. This study employed quantitative meta-analysis to investigate the association between sexual violence and CVD risk.

methodsPubMed and PsycINFO databases were searched through March 1, 2021. Included articles had a measure of sexual violence and at least one cardiovascular outcome (i.e., clinical CVD, subclinical CVD, select CVD risk factors) in women and men aged 18 years or older. Data were expressed as odds ratios (OR) or hazard ratios (HR) with 95% confidence intervals (CI) extracted from fully-adjusted models. OR and HR effects were pooled separately, given the inability to statistically harmonize these effects and differences in interpretation, using random effects meta-analysis. Heterogeneity of effects was tested using Cochran's Q test.

resultsOverall, 45 articles based on 830,579 adults (77.1% women) were included (113 individual effects expressed as OR and 9 individual effects expressed as HR). Results indicated that sexual violence was related to adult CVD risk (OR [95%CI] = 1.25 [1.11-1.40]; HR [95%CI] = 1.17 [1.05-1.31]). Results varied by outcome type and measurement, and timing of violence.

conclusionsAdults with a history of sexual violence demonstrate greater CVD risk relative to those without this history. The results highlight the importance of addressing sexual violence in CVD risk reduction efforts.

Indexed as

Cardiovascular DiseasesAdultAdult Survivors of Child AbuseChildChild Abuse, SexualCross-Sectional StudiesFemaleHumansMaleMetabolic DiseasesRisk FactorsSex OffensesCardiovascular diseasesChildhood sexual abuseMeta-analysisMetabolic diseasesSexual violenceWomen

Identifiers

PMID34654528
PMCPMC8531533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.