Evidence map›Paper›PMID 34654471›Full record

ReviewJournal of eating disorders2021

Efficacy of post-inpatient aftercare treatments for anorexia nervosa: a systematic review of randomized controlled trials.

Katrin E Giel, Simone C Behrens, Kathrin Schag, Peter Martus, Stephan Herpertz, Tobias Hofmann, Eva-Maria Skoda, Ulrich Voderholzer, Jörn von Wietersheim, Beate Wild and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Patient and carer feedback and engagement with ECHOMANTRA, a digital guided intervention for anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Does anorexia nervosa with adolescent onset need long-term follow-up?Pediatric endocrinology, diabetes, and metabolism · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 2 countries.

Katrin E GielDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Eberhard Karls University, Osianderstr. 5, 72076, Tübingen, Germany. katrin.giel@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0003-0938-4402
Simone C BehrensDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Eberhard Karls University, Osianderstr. 5, 72076, Tübingen, Germany.
Kathrin SchagDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Eberhard Karls University, Osianderstr. 5, 72076, Tübingen, Germany.
Peter MartusInstitute for Clinical Epidemiology and Applied Biostatistics, Medical Faculty, Eberhard Karls University Tübingen, Tübingen, Germany.
Stephan HerpertzDepartment of Psychosomatic Medicine and Psychotherapy, LWL-University Hospital Bochum, Ruhr University Bochum, Bochum, Germany.
Tobias HofmannDepartment of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
Eva-Maria SkodaClinic for Psychosomatic Medicine and Psychotherapy, LVR University-Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ulrich VoderholzerSchoen Clinic Roseneck, Prien am Chiemsee, Germany.
Jörn von WietersheimDepartment of Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, Ulm, Germany.
Beate WildDepartment of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany.
Almut ZeeckDepartment of Psychosomatic Medicine und Psychotherapy, Center for Mental Health, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ulrike SchmidtSection of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Stephan ZipfelDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Eberhard Karls University, Osianderstr. 5, 72076, Tübingen, Germany.
Florian JunneDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Eberhard Karls University, Osianderstr. 5, 72076, Tübingen, Germany.
Bernstein Center for Computational Neuroscience Tübingen · DEUniversity of Tübingen · DEHeidelberg University · DEHumboldt-Universität zu Berlin · DEKing's College London · GBLWL-Universitätsklinikum Bochum · DEUniversität Ulm · DEUniversity Medical Center Freiburg · DEUniversity of Duisburg-Essen · DEUniversity of Freiburg · DE

Funding

Bundesministerium für Bildung und Forschung 01KG2009
6 · The paper itself

Abstract

backgroundEarly relapse after inpatient treatment is a serious problem in the management of anorexia nervosa (AN). Specialized aftercare interventions have the potential to bridge the gap between inpatient and outpatient care, to prevent relapse and to improve the long-term outcome for patients with AN.

methodsFollowing the guidelines of the PRISMA statement, we conducted a systematic review, synthesizing the evidence from randomized-controlled trials (RCTs) investigating the efficacy of post-inpatient aftercare treatments for AN.

resultsOur search resulted in seven RCTs and three registered ongoing trials. Pharmacotherapy and low-threshold guided self-help have limited uptake and high dropout. Novel mobile guided self-help approaches seem promising due to high patient satisfaction, but their efficacy has yet to be investigated in larger trials. Cognitive-behavior psychotherapy may be beneficial in delaying relapse, but evidence is based on a single study.

conclusionOnly a limited number of RCTs investigating aftercare interventions for patients with AN is available. There is no clear evidence favoring any one specific approach for post-inpatient aftercare in adult patients with AN. The field faces many challenges which generally affect intervention research in AN. A specific issue is how to increase uptake of and reduce dropout from aftercare interventions. This calls for better tailoring of interventions to patient needs and the integration of patient perspectives into treatment. Intensified research and care efforts are needed to address the problem of recurrent relapse after intensive inpatient treatment for AN and to eventually improve prognosis for this eating disorder.

Indexed as

AftercareAnorexia nervosaEating disorderEfficacyRandomized-controlled trialsRelapseTherapyTreatment

Identifiers

PMID34654471
PMCPMC8518230
OpenAlexW3207608381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.