Evidence map›Paper›PMID 34654458›Full record

ArticleJournal of neuroinflammation2021

Functional role of brain-engrafted macrophages against brain injuries.

Xi Feng, Elma S Frias, Maria S Paladini, David Chen, Zoe Boosalis, McKenna Becker, Sonali Gupta, Sharon Liu, Nalin Gupta, Susanna Rosi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xi FengBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.
Elma S FriasBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.
Maria S PaladiniBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.
David ChenBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.
Zoe BoosalisBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.
McKenna BeckerBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.
Sonali GuptaBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA.
Sharon LiuDepartment of Neurological Surgery, University of California San Francisco, San Francisco, USA.
Nalin GuptaDepartment of Neurological Surgery, University of California San Francisco, San Francisco, USA.
Susanna RosiBrain and Spinal Injury Center, University of California San Francisco, San Francisco, USA. Susanna.Rosi@ucsf.edu.ORCID http://orcid.org/0000-0002-9269-3638
San Francisco General Hospital · USUniversity of California, San Francisco · US

Funding

Therapeutic Irradiation and Brain FunctionsR01CA213441 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUPTA, NALIN · 2017 to 2021
$1.8M
Aging exacerbates trauma-induced immune pathways and neuronal dysfunctionR01AG056770 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSI, SUSANNA · 2017 to 2021
$1.7M
Brain Irradiation Affects Neuronal FunctionR01CA133216 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSI, SUSANNA · 2009 to 2013
$1.5M
Foundation for the National Institutes of Health R01AG056770Foundation for the National Institutes of Health R01CA133216Foundation for the National Institutes of Health R01CA213441NCI NIH HHS R01 CA133216NCI NIH HHS R01 CA213441NIA NIH HHS R01 AG056770
6 · The paper itself

Abstract

backgroundBrain-resident microglia have a distinct origin compared to macrophages in other organs. Under physiological conditions, microglia are maintained by self-renewal from the local pool, independent of hematopoietic progenitors. Pharmacological depletion of microglia during whole-brain radiotherapy prevents synaptic loss and long-term recognition memory deficits. However, the origin or repopulated cells and the mechanisms behind these protective effects are unknown.

methodsCD45

resultsAfter a combination of whole-brain radiotherapy and microglia depletion, repopulated cells are brain-engrafted macrophages that originate from circulating monocytes. Comparisons of transcriptomes reveal that brain-engrafted macrophages have an intermediate phenotype that resembles both monocytes and embryonic microglia. In addition, brain-engrafted macrophages display reduced phagocytic activity for synaptic compartments compared to microglia from normal brains in response to a secondary concussive brain injury. Importantly, replacement of microglia by brain-engrafted macrophages spare mice from whole-brain radiotherapy-induced long-term cognitive deficits, and prevent concussive injury-induced memory loss.

conclusionsBrain-engrafted macrophages prevent radiation- and concussion-induced brain injuries and cognitive deficits.

Indexed as

Dose Fractionation, RadiationAnimalsBrainBrain InjuriesMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicBrain-engrafted macrophagesBrain irradiationCognitionCSF-1R inhibitorMicroglia

Identifiers

PMID34654458
PMCPMC8520231
OpenAlexW3207634476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.