Evidence map›Paper›PMID 34654425›Full record

ArticleMolecular cancer2021

DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.

Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan and 15 more

Open access · goldAbstract readLetter
In one paragraph

Article in Molecular cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. AnBioengineering & translational medicine · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. A Dual Role of DDX3X in dsRNA-Derived Innate Immune Signaling.Frontiers in molecular biosciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 2 countries.

Atish Kizhakeyil *Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, Singapore, 308232, Singapore.
Nurmahirah Binte Mohammed Zaini *Department of Haematology, Singapore General Hospital, The Academia, Level 3, 20 College Road, Singapore, 169856, Singapore.
Zhi Sheng Poh *Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, Singapore, 308232, Singapore.
Brandon Han Siang WongLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, Singapore, 308232, Singapore.
Xinpeng LohSchool of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Dr, Singapore, 637551, Singapore.
Aik Seng NgLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, Singapore, 308232, Singapore.
Zun Siong LowLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, Singapore, 308232, Singapore.
Praseetha PrasannanLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, Singapore, 308232, Singapore.
Chun GongWellcome MRC Cambridge Stem Cell Institute, Cambridge, UK.
Michelle Guet Khim TanClinical Translational Sciences, Singapore General Hospital, The Academia Level 9, 20 College Road, Singapore, 169856, Singapore.
Chandramouli NagarajanDepartment of Haematology, Singapore General Hospital, The Academia, Level 3, 20 College Road, Singapore, 169856, Singapore.
Dachuan HuangLymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.
Pang Wan LuLymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.
Jing Quan LimLymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.
Sharon BarransHaematological Malignancy Diagnostic Service (HMDS), St. James's Institute of Oncology, Leeds, UK.
Choon Kiat OngLymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.
Soon Thye LimDirector's office, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.
Wee Joo ChngNational University Cancer Institute, Singapore, Singapore.
George FollowsAddenbrooke's Hospital NHS Foundation Trust, Cambridge, UK.
Daniel J HodsonWellcome MRC Cambridge Stem Cell Institute, Cambridge, UK.
Ming Qing DuDepartment of Pathology, University of Cambridge, Cambridge, UK.
Yeow Tee GohDepartment of Haematology, Singapore General Hospital, The Academia, Level 3, 20 College Road, Singapore, 169856, Singapore.
Suat Hoon TanNational Skin Centre Singapore, 1 Mandalay Road, Singapore, 308205, Singapore.
Nicholas Francis Grigoropoulos *Department of Haematology, Singapore General Hospital, The Academia, Level 3, 20 College Road, Singapore, 169856, Singapore. nicholas.francis.grigoropoulos@singhealth.com.sg.
Navin Kumar Verma *Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, Singapore, 308232, Singapore. nkverma@ntu.edu.sg.ORCID 0000-0002-5940-6633
Nanyang Technological University · SGSingapore General Hospital · SGNational Cancer Centre Singapore · SGDuke-NUS Medical School · SGNational Skin Centre · SGWellcome/MRC Cambridge Stem Cell Institute · GBCambridge University Hospitals NHS Foundation Trust · GBNational University of Singapore · SGSingHealth · SGSt James's University Hospital · GBUniversity of Cambridge · GB

Funding

Cancer Research UK A25117kay kendall leukaemia fund KKL649Medical Research Council MR/M008584/1ministry of education - singapore MOE2017-T2-2-004nanyang technological university L0412290national medical research council NMRC/TA/0051/2016national medical research council OFLCG18May-0028Wellcome Trust 203151/Z/16/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomarkers, TumorAntineoplastic AgentsCell Line, TumorCyclin D1DEAD-box RNA HelicasesDisease ProgressionDrug Resistance, NeoplasmExome SequencingHumansLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMitogen-Activated Protein KinasesMutationPrognosisSTAT3 Transcription FactorAntineoplastic AgentsBiomarkers, TumorCyclin D1DDX3X protein, humanDEAD-box RNA HelicasesMitogen-Activated Protein KinasesSTAT3 protein, humanSTAT3 Transcription FactorDDX3X mutationDrug resistanceHematolymphoid malignancyPrognosisTumour metastasis

Identifiers

PMID34654425
PMCPMC8520256
OpenAlexW3206043527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.