ArticleCancer control : journal of the Moffitt Cancer Center
Clinicopathological Characteristics and Prognosis of Squamous Cell Carcinoma of the Breast: A Population-Based Analysis.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- A rare case of HER2-positive pure metaplastic squamous cell carcinoma of the breast.Discover oncology · 2025Article
- Therapeutic Management in Elderly Male Breast Cancer Patients: A Scoping Review.Current oncology reports · 2025Article
- An Unusual Occurrence of Synchronous Squamous Cell Carcinoma and Invasive Ductal Carcinoma in the Ipsilateral Breast: A Case ReportCurrent medical imaging · 2025Article
- Primary squamous cell carcinoma of the breast: a case report.Discover oncology · 2024Article
- Neoadjuvant therapy for HER2-positive acantholytic squamous cell breast carcinoma: a case report.The Journal of international medical research · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundTo better understand the clinicopathological features and prognostic profiles of squamous cell carcinoma (SCC) of the breast.
methodsInformation on breast cancer was obtained from the Surveillance, Epidemiology, and End Results database (2004-2016). Comparative analyses were carried out to investigate the heterogeneity in the clinicopathological characteristics and survival outcomes between SCC and invasive ductal carcinoma (IDC), while propensity score matching was conducted to analyze the variations among baseline characteristics. Prognostic factors for SCC of the breast were successively identified using Cox regression analysis.
resultsA total of 382 SCC patients and 561477 IDC patients were identified in this study. Comparatively, the SCC cohort exhibited a higher proportion of male individuals, poor differentiation, an advanced TNM stage, an increasing percentage of triple-negative (TN) subtype, an increasing rate of organ involvement, and less access to therapeutics. The aggressive profile was consistent in the TN subgroup, with a significantly higher proportion in SCC than in IDC (25.7% vs 6.8%). Prognosis of SCC was profoundly poorer than that of IDC (mOS, 78.6 months and 121.6 months,
conclusionsThis study systematically analyzed the heterogeneous characteristics of SCC of the breast in comparison with IDC. Squamous cell breast cancer presented with increasing aggressive behavior and inferior prognosis. Prospective studies should focus on this subgroup and introduce individualized therapeutic protocols in clinical practice.
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