ArticleEuropean geriatric medicine2018
The adverse drug reaction risk in older persons (ADRROP) prediction scale: derivation and prospective validation of an ADR risk assessment tool in older multi-morbid patients.
Article in European geriatric medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Risk prediction models for adverse drug reactions and adverse drug events in older adults-a systematic review and meta-analysis.European journal of clinical pharmacology · 2025Pooled it
- Implementation of a medicine management plan (MMP) to reduce medication-related harm (MRH) in older people post-hospital discharge: a randomised controlled trial.BMC geriatrics · 2022Trial
- Prediction tools to prioritise hospitalised adult patients at risk of drug related problems: An umbrella review.PLOS digital health · 2026Article
- Article
- Adverse drug reactions and events in an Ageing PopulaTion risk Prediction (ADAPTiP) tool: the development and validation of a model for predicting adverse drug reactions and events in older patients.European geriatric medicine · 2025Article
- Prevalence and risk factors of self-reported adverse drug events in elderly co-morbid patients in northeastern China: a cross-sectional study.BMC geriatrics · 2025Article
- Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia.Drugs & aging · 2024Article
- Comprehensive Multimorbidity Patterns in Older Patients Are Associated with Quality Indicators of Medication-MoPIM Cohort Study.International journal of environmental research and public health · 2022Observational
- Systematic Review of Risk Factors Assessed in Predictive Scoring Tools for Drug-Related Problems in Inpatients.Journal of clinical medicine · 2022Review
- Clinical significance of potential drug-drug interactions in older adults with psychiatric disorders: a retrospective study.BMC psychiatry · 2022Article
- Performance of a trigger tool for detecting adverse drug reactions in patients with polypharmacy acutely admitted to the geriatric ward.European geriatric medicine · 2022Article
- Predictors of hospital-acquired adverse drug reactions: a cohort of Ugandan older adults.BMC geriatrics · 2022Article
- Adverse drug reactions in an ageing PopulaTion (ADAPT) study: Prevalence and risk factors associated with adverse drug reaction-related hospital admissions in older patients.Frontiers in pharmacology · 2022Article
- Development and Validation of 'Prediction of Adverse Drug Reactions in Older Inpatients (PADROI)' Risk Assessment Tool.Clinical interventions in aging · 2022Article
- Prevalence, characteristics and predicting risk factors of adverse drug reactions among hospitalized older adults: A systematic review and meta-analysis.SAGE open medicine · 2021Review
- The clinical and therapeutic challenge of treating older patients in clinical practice.British journal of clinical pharmacology · 2020Review
- Article
- Screening Tools Used by Clinical Pharmacists to Identify Elderly Patients at Risk of Drug-Related Problems on Hospital Admission: A Systematic Review.Pharmacy (Basel, Switzerland) · 2020Review
- Medication-related harm in older adults following hospital discharge: development and validation of a prediction tool.BMJ quality & safety · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAdverse drug reactions (ADRs) cause serious morbidity and mortality in multi-morbid older adults. Reliable ADR risk prediction would improve patient safety in this at-risk population. We aimed to derive and validate a new predictive tool for assessing ADR Risk in Older People (acronym ADRROP).
designWe combined four databases describing 2217 older people hospitalized with acute illness in order to determine risk factor variables significantly associated with ADRs. We identified the independent ADR risk factors from 1687 patients (derivation cohort) and used them to construct the ADRROP scale. We prospectively validated ADRROP using data from 530 patients (validation cohort). We applied area under the curve (AUC) analysis to test ADRROP's ADR predictive power. We also compared ADRROP's performance to the GerontoNet ADR risk scale.
resultsEight independent ADR risk factors were identified in the derivation patient cohort: female gender, age > 70 years, estimated GFR < 30 ml/min/1.73 m CONCLUSIONS AND RELEVANCE: Neither ADRROP nor the GerontoNet ADR risk scale predicted ADRs to a high level in hospitalized older people with multi-morbidity.
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