ArticleEuropean geriatric medicine2018
Proton pump inhibitors therapy and the risk of hip fracture in older people in Taiwan.
Article in European geriatric medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 18 citations in OpenAlex.
- Effect of long-term proton pump inhibitors on phosphocalcium metabolism and bone mineral density.Future science OA · 2024Article
- Proton Pump Inhibitors and Fractures in Adults: A Critical Appraisal and Review of the Literature.International journal of endocrinology · 2021Review
- Proton Pump Inhibitors and Fracture Risk: A Review of Current Evidence and Mechanisms Involved.International journal of environmental research and public health · 2019Review
- Association between colorectal cancer and thiazolidinediones administration in a case-control study.BioMedicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionConflicting results exist on the relationship between proton pump inhibitors use and hip fracture in old people. The objective of the paper was to explore this issue in Taiwan.
methodsWe conducted a population-based case-control study using the database of the Taiwan National Health Insurance Program. Cases included subjects aged 65 years and over with newly diagnosed hip fracture between 2000 and 2013 (n = 7208). Controls included subjects aged 65 years and over without a diagnosis of hip fracture (n = 7208). The cases and the controls were matched with sex, age, comorbidities, and index year of diagnosing hip fracture. The odds ratio and 95% confidence interval for hip fracture associated with proton pump inhibitors use were estimated by the multivariable logistic regression model.
resultsThe adjusted odds ratio of hip fracture was 0.96 for subjects with current use of proton pump inhibitors (95% confidence interval 0.76, 1.22), 1.17 for subjects with recent use (95% confidence interval 0.90, 1.52), and 1.12 for subjects with late use (95% confidence interval 0.91, 1.38), compared with never use.
conclusionsNo significant association can be detected between proton pump inhibitors use and the risk of hip fracture in older people in Taiwan.
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Registered trials
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