Evidence map›Paper›PMID 34653787›Full record

ReviewCurrent opinion in immunology2021

Functional heterogeneity and adaptation of naive T cells in response to tonic TCR signals.

Joel Eggert, Byron B Au-Yeung

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Zeaxanthin augments CD8Cell reports. Medicine · 2025
    Article
  5. The LDH-H3K18La-Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. The insulin signalling network.Nature metabolism · 2025
    Review
  7. A Dapl1Science advances · 2025
    Article
  8. Article
  9. Article
  10. What's the Catch? The Significance of Catch Bonds in T Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joel EggertDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, United States.
Byron B Au-YeungDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, United States. Electronic address: byron.au-yeung@emory.edu.
Emory University · US

Funding

Inhibition of ZAP-70 to selectively attenuate autoimmune disease-inducing T cellsK01AR065481 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AU-YEUNG, BYRON BENTON · 2014 to 2016
$385k
NIAMS NIH HHS K01 AR065481
6 · The paper itself

Abstract

Mature CD4

Indexed as

AnimalsAutoantigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationHumansImmune ToleranceLymphocyte ActivationReceptors, Antigen, T-CellSignal TransductionAutoantigensReceptors, Antigen, T-Cell

Identifiers

PMID34653787
PMCPMC8648992
OpenAlexW3206203350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.