Evidence map›Paper›PMID 34653546›Full record

ArticleBiological psychology2021

Children with developmental dyslexia show elevated parasympathetic nervous system activity at rest and greater cardiac deceleration during an empathy task.

Eleanor R Palser, Nathaniel A Morris, Ashlin R K Roy, Sarah R Holley, Christina R Veziris, Christa Watson, Jessica Deleon, Zachary A Miller, Bruce L Miller, Maria Luisa Gorno-Tempini and 1 more

Abstract read
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In one paragraph

Article in Biological psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eleanor R PalserDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Nathaniel A MorrisDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Ashlin R K RoyDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Sarah R HolleyPsychology Department, San Francisco State University, San Francisco, CA 94132, USA; Department of Psychiatry, University of California, San Francisco, CA 94131, USA.
Christina R VezirisDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Christa WatsonDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Jessica DeleonDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Zachary A MillerDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Bruce L MillerDepartment of Neurology, University of California, San Francisco, CA 94158, USA.
Maria Luisa Gorno-TempiniDepartment of Neurology, University of California, San Francisco, CA 94158, USA; Department of Psychiatry, University of California, San Francisco, CA 94131, USA.
Virginia E SturmDepartment of Neurology, University of California, San Francisco, CA 94158, USA; Department of Psychiatry, University of California, San Francisco, CA 94131, USA. Electronic address: virginia.sturm@ucsf.edu.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS P01 AG019724NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

Reading difficulties are the hallmark feature of dyslexia, but less is known about other areas of functioning. Previously, we found children with dyslexia exhibited heightened emotional reactivity, which correlated with better social skills. Whether emotional differences in dyslexia extend to the parasympathetic nervous system-an autonomic branch critical for attention, social engagement, and empathy-is unknown. Here, we measured autonomic nervous system activity in 24 children with dyslexia and 24 children without dyslexia, aged 7 - 12, at rest and during a film-based empathy task. At rest, children with dyslexia had higher respiratory sinus arrhythmia (RSA) than those without dyslexia. Cardiac deceleration during the empathy task was greater in dyslexia and correlated with higher resting RSA across the sample. Children with dyslexia produced more facial expressions of concentration during film-viewing, suggesting greater engagement. These results suggest elevated resting parasympathetic activity and accentuated autonomic and behavioral responding to others' emotions in dyslexia.

Indexed as

DyslexiaRespiratory Sinus ArrhythmiaChildDecelerationEmotionsEmpathyHumansParasympathetic Nervous SystemCompassionEmotion recognitionNeurodiversitySocial behavior

Identifiers

PMID34653546
PMCPMC11721162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.