ArticleEpilepsia open2021
Classifying etiology of infantile spasms syndrome in resource-limited settings: A study from the South Asian region.
Article in Epilepsia open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and incidence of infantile epileptic spasms syndrome in India: A systematic review and meta-analysis.Epilepsia open · 2026Pooled it
- Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms.Annals of clinical and translational neurology · 2025Trial
- Screening children and adolescents with mild to moderate intellectual disability for autistic symptoms with the Indian Autism Screening Questionnaire (IASQ).Indian journal of psychiatry · 2026Article
- Etiological Analysis and Classification of 108 Patients with Infantile Epileptic Spasms Syndrome Based on the 2017 International League Against Epilepsy Classification.Noro psikiyatri arsivi · 2026Article
- A model-based cost-effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome.Epilepsia open · 2025Observational
- First-choice hormonal therapies for children with infantile epileptic spasms syndrome in South Asia: A network meta-analysis of randomized controlled trials.Epilepsia open · 2024Review
- Genetic Advancements in Infantile Epileptic Spasms Syndrome and Opportunities for Precision Medicine.Genes · 2024Review
- Landscape of genetic infantile epileptic spasms syndrome-A multicenter cohort of 124 children from India.Epilepsia open · 2023Article
- COVID-19 in Children with West Syndrome: An Ambispective Study.Indian journal of pediatrics · 2023Article
- Demographic characteristics and clinical presentation of infants with infantile epileptic spasms syndrome and their response to therapy: Data from Sri Lanka Infantile Spasms Registry.Annals of the Child Neurology Society · 2023Article
- The landscape of infantile epileptic spasms syndrome in South Asia: peculiarities, challenges, and way forward.The Lancet regional health. Southeast Asia · 2023Review
- Classifying etiology of infantile spasms syndrome in resource-limited settings: A study from the South Asian region.Epilepsia open · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveEtiological classification of infantile spasms syndrome (ISS) is important, considering the influence on prognosis based on the presence or absence of a known etiology. This study was performed to describe the limitations and difficulties experienced within the South Asian region when classifying the etiology of ISS according to the current recommendation.
methodData on healthcare indices and facilities related to management of ISS for the nine countries in the South Asian region were gathered by the South Asian West Syndrome Research Group. A Google survey was performed among three hundred and thirty pediatric neurologists in the region. The capacity within each country for investigating etiology of ISS according to current described benchmarks was evaluated. The difficulties experienced in this regard and the potential solutions were investigated.
resultsOne hundred and sixty pediatric neurologists (response rate 48%) from Bangladesh (19/25), India (94/255), Myanmar (11/11), Nepal (6/8), Pakistan (19/25), and from Sri Lanka (7/8) responded. Three countries had no pediatric neurology services. Fifty-six percent attempted to classify ISS etiology according to classification outlined by International League Against Epilepsy in 2017. The facilities to perform metabolic, genetic, and immunological investigations were very limited. Lack of funding for investigations and poor laboratory support were the two most frequent barriers encountered. Sixty percent indicated that a separate classification is suitable for low-income setting; 78% suggested inclusion of separate category as "incompletely investigated" as an alternative solution to mitigate the barrier of achieving a better understanding of the etiological subtypes seen more frequently in this region. SIGNIFICANCE: The resources in South Asian region are limited to meet the recommendations for investigating etiology of ISS. Including the etiological subcategory "incompletely investigated" is proposed as an alternative to understand the true proportions of children in this region, with a definite known etiology and those with an unknown etiology.
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