Evidence map›Paper›PMID 34653177›Full record

ArticlePloS one2021

Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.

Po-Ke Hsu, Li-Sha Wu, Wei-Wen Su, Pei-Yuan Su, Yang-Yuan Chen, Yu-Chun Hsu, Hsu-Heng Yen, Chia-Lin Wu

RetractedAbstract readComparative StudyRetracted Publication
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Po-Ke HsuDepartment of Gastroenterology, Changhua Christian Hospital, Changhua County, Taiwan.ORCID 0000-0003-0828-5680
Li-Sha WuDepartment of Ultrasound, Changhua Christian Hospital, Changhua County, Taiwan.
Wei-Wen SuDepartment of Gastroenterology, Changhua Christian Hospital, Changhua County, Taiwan.
Pei-Yuan SuDepartment of Gastroenterology, Changhua Christian Hospital, Changhua County, Taiwan.
Yang-Yuan ChenDepartment of Gastroenterology, Changhua Christian Hospital, Changhua County, Taiwan.
Yu-Chun HsuDepartment of Gastroenterology, Changhua Christian Hospital, Changhua County, Taiwan.
Hsu-Heng YenDepartment of Gastroenterology, Changhua Christian Hospital, Changhua County, Taiwan.ORCID 0000-0002-3494-2245
Chia-Lin WuSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsIn a recent study, attenuation imaging (ATI) with ultrasound was used as a new approach for detecting liver steatosis. However, although there are many studies on ATI and controlled attenuation parameter (CAP) that prove their practicability, there are few studies comparing these two methods. As such, this study compared CAP and ATI for the detection and evaluation of liver steatosis.

methodsA prospective analysis of 28 chronic liver disease patients who underwent liver biopsy, FibroScan® imaging, and ATI with ultrasound was conducted. The presence and degree of steatosis, as measured with the FibroScan® device and ATI, were compared with the pathological results obtained using liver biopsy.

resultsThe areas under the receiver operating characteristic curve (AUROC) of ATI and CAP for differentiating between normal and hepatic steatosis were 0.97 (95% confidence interval [CI] 0.83-1.00) and 0.96 (95% CI 0.81-0.99), respectively. ATI has a higher AUROC than CAP does in liver steatosis, at 0.99 (95% CI, 0.86-1.00) versus 0.91 (95% CI, 0.74-0.98) in grade ≥ 2 and 0.97 (95% CI, 0.82-1.00) versus 0.88 (95% CI, 0.70-0.97) in grade = 3, respectively.

conclusionThe ATI and CAP results showed good consistency and accuracy for the steatosis grading when compared with the liver biopsy results. Moreover, ATI is even better than CAP in patients with moderate or severe steatosis. Therefore, ATI represents a non-invasive and novel diagnostic tool with which to support the diagnosis of liver steatosis in clinical practice.

Indexed as

AdultAgedAged, 80 and overArea Under CurveElasticity Imaging TechniquesFemaleHumansLiverMagnetic Resonance ImagingMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseProspective StudiesSeverity of Illness IndexUltrasonographyYoung Adult

Identifiers

PMID34653177
PMCPMC8519468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.