Evidence map›Paper›PMID 34652998›Full record

ArticleIEEE transactions on medical imaging2022

Direct Reconstruction of Linear Parametric Images From Dynamic PET Using Nonlocal Deep Image Prior.

Kuang Gong, Ciprian Catana, Jinyi Qi, Quanzheng Li

Abstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Applications of artificial intelligence in nuclear medicine.Zeitschrift fur medizinische Physik · 2026
    Review
  2. Article
  3. A Cross-modality Transformer Network for MR-guided Low-dose Tau PET Image Denoising.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Machine learning methods for tracer kinetic modelling.Nuklearmedizin. Nuclear medicine · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.European journal of nuclear medicine and molecular imaging · 2023
    Review
  15. AI for PET image reconstruction.The British journal of radiology · 2023
    Review
  16. Review
  17. Article
  18. Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  19. Deep Kernel Representation for Image Reconstruction in PET.IEEE transactions on medical imaging · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kuang Gong
Ciprian Catana
Jinyi Qi
Quanzheng Li

Funding

Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)P01AG036694 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Rebecca E Amariglio · 2010 to 2026
$50.2M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Kira Grogg · 2017 to 2026
$14.8M
Methods for Quantitative Neuroimaging of Tau Burden inPre-symptomatic ADR01AG076153 · NIA · YALE UNIVERSITY · PI Georges El Fakhri, Marc David Normandin · 2022 to 2026
$3.0M
Study of Brain Spreading Pathways of Tau and Amyloid-Beta in (pre)clinical ADRF1AG052653 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LI, QUANZHENG, SEPULCRE, JORGE · 2017 to 2017
$1.4M
Correction of Partial Volume Effects in PET for Alzheimer's Disease Using Unsupervised Deep LearningR21AG067422 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GONG, KUANG · 2020 to 2020
$453k
Optimization of PET Image Reconstruction for Lesion DetectionR03EB030280 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI GONG, KUANG · 2020 to 2021
$184k
NIA NIH HHS P01 AG036694NIA NIH HHS R01 AG076153NIA NIH HHS R21 AG067422NIA NIH HHS RF1 AG052653NIBIB NIH HHS P41 EB022544NIBIB NIH HHS R03 EB030280
6 · The paper itself

Abstract

Direct reconstruction methods have been developed to estimate parametric images directly from the measured PET sinograms by combining the PET imaging model and tracer kinetics in an integrated framework. Due to limited counts received, signal-to-noise-ratio (SNR) and resolution of parametric images produced by direct reconstruction frameworks are still limited. Recently supervised deep learning methods have been successfully applied to medical imaging denoising/reconstruction when large number of high-quality training labels are available. For static PET imaging, high-quality training labels can be acquired by extending the scanning time. However, this is not feasible for dynamic PET imaging, where the scanning time is already long enough. In this work, we proposed an unsupervised deep learning framework for direct parametric reconstruction from dynamic PET, which was tested on the Patlak model and the relative equilibrium Logan model. The training objective function was based on the PET statistical model. The patient's anatomical prior image, which is readily available from PET/CT or PET/MR scans, was supplied as the network input to provide a manifold constraint, and also utilized to construct a kernel layer to perform non-local feature denoising. The linear kinetic model was embedded in the network structure as a 1 ×1 ×1 convolution layer. Evaluations based on dynamic datasets of

Indexed as

Image Processing, Computer-AssistedPositron Emission Tomography Computed TomographyAlgorithmsFluorodeoxyglucose F18HumansPositron-Emission TomographySignal-To-Noise RatioFluorodeoxyglucose F18

Identifiers

PMID34652998
PMCPMC8956450

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.