ArticleGlobal health action2021
Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa.
Article in Global health action, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Bridging Programmatic Gap in Post-TB Treatment Prevention: Applying the COM-B Model and Behavior Change Wheel to Improve the Uptake of TB Preventive Therapy.Open forum infectious diseases · 2026Article
- "They hide because they fear": Barriers and opportunities for tuberculosis control in rural Indonesia through the PRECEDE-PROCEED lens.Journal of public health research · 2026Article
- Between Process Gaps, Knowledge, and Patient Trust: Healthcare Workers' Insights on Implementing Tuberculosis Preventive Therapy for People with HIV in the Philippines and Indonesia.Implementation science communications · 2025Article
- 'And the stick to fight TB is TPT': nurse-identified barriers and facilitators of tuberculosis preventive therapy implementation in rural South Africa.BMJ open respiratory research · 2025Article
- Article
- Advancement in diagnostic approaches for latent tuberculosis: distinguishing recent from remote infections.One health outlook · 2025Review
- "Now that I took TPT, it's affecting my ART adherence, viral load, even my wellbeing in the community". Exploring acceptability and experience of Tuberculosis Preventive Treatment among adolescents living with HIV in Zimbabwe.PLOS global public health · 2025Article
- Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients-Patients' and Healthcare Workers' Perspectives.Tropical medicine and infectious disease · 2024Article
- Challenges of Screening and Investigations of Contacts of Patients with Tuberculosis in Oyo and Osun States, Nigeria.Tropical medicine and infectious disease · 2024Article
- Barriers and facilitators of implementing electronic monitors to improve adherence and health outcomes in tuberculosis patients: protocol for a systematic review based on the Consolidated Framework for Implementation Research.Health research policy and systems · 2023Article
- Roles and challenges of nurses in tuberculosis care in Africa: A narrative review.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Review
- They do not have symptoms - why do they need to take medicines? Challenges in tuberculosis preventive treatment among children in Cambodia: a qualitative study.BMC pulmonary medicine · 2023Article
- Management of Tuberculosis Infection: Current Situation, Recent Developments and Operational Challenges.Pathogens (Basel, Switzerland) · 2023Review
- Strategic approach to optimisation of TB contact investigation in Nigeria.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- Perceptions of Teamwork and Knowledge Attitudes of Hemodialysis Unit Nurses on Infection Prevention.Advances in experimental medicine and biology · 2023Article
- Development of an infectious disease prevention behavior model for public health center workers in a rural area of Indonesia.Journal of public health in Africa · 2022Article
- Incidence of active tuberculosis among people living with HIV receiving long-term antiretroviral therapy in high TB/HIV burden settings in Thailand: implication for tuberculosis preventive therapy.Journal of the International AIDS Society · 2022Article
- Using implementation science to evaluate perceived feasibility of pharmacy-based HIV services in the Southeastern United States.Journal of the American Pharmacists Association : JAPhAArticle
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundDespite extensive rollout of tuberculosis preventive therapy (TPT) in South Africa to reduce the incidence of tuberculosis among people living with HIV (PWH), rates of initiation and completion have remained suboptimal.
objectiveThis study aimed to identify factors associated with low TPT prescription rates among health care workers (HCWs) in rural South Africa.
methodsA cross-sectional study was conducted using an anonymous 39-item questionnaire guided by the Consolidated Framework for Implementation Research (CFIR). HCWs from a government district hospital and 14 primary healthcare clinics (PHCs) in the rural Msinga sub-district of KwaZulu-Natal were surveyed from November 2019 to January 2020. Self-reported data on prescription rates as well as knowledge, attitudes, beliefs, and practices regarding isoniazid preventative therapy, the current TPT regimen, were obtained. Factor analysis and logistic regression were used to determine associations with low prescription rates (< 50% of PWH) for TPT prescribers, and results were placed within CFIR-driven context.
resultsAmong 160 HCWs, the median (IQR) age was 39 (33-46) years, 76% were women, 78% worked at a PHC, and 44% had experience prescribing TPT. On multivariable analysis, prescribers (n = 71) who believed their patients would not disclose TPT use to others were significantly less likely to prescribe TPT (aOR 4.19 95% CI 1.35-13.00; p = 0.01). Inadequate isoniazid supplies trended towards significance (aOR 10.10 95% CI 0.95-106.92; p = 0.06) in association with low prescription rates.
conclusionsStrengthening HCW training to emphasize TPT prescription to all eligible PWH regardless of beliefs about patient disclosure and ensuring a consistent isoniazid supply at the health systems-level are both critical steps to enhancing TPT implementation in rural South Africa.
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Registered trials
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