ArticleHuman brain mapping2022
Tormenting thoughts: The posterior cingulate sulcus of the default mode network regulates valence of thoughts and activity in the brain's pain network during music listening.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The Relative Accuracy of Different Methods for Measuring Mind Wandering Subtypes: A Systematic Review.Brain and behavior · 2025Pooled it
- Effects of a randomised trial of 5-week heart rate variability biofeedback intervention on mind wandering and associated brain function.Cognitive, affective & behavioral neuroscience · 2022Trial
- Relationship Between Affective Valence of Mind Wandering and Mood: The Role of Resting-State Functional Connectivity.Scandinavian journal of psychology · 2026Article
- Objective assessment of familiarity in music using imagery and EEG-based machine learning.Scientific reports · 2026Article
- Inefficient default mode network hyperconnectivity characterizes chronic low back-related leg pains: a static and dynamic functional MRI study.Brain imaging and behavior · 2026Article
- Functional Connectivity Changes of Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Graph-Theoretic and Topology-Based Study.Brain and behavior · 2025Article
- Music-Evoked Nostalgia Activates Default Mode and Reward Networks Across the Lifespan.Human brain mapping · 2025Article
- The role of active music making in fostering resilience.Frontiers in neuroscience · 2025Article
- Neurodevelopmental signature of a transcriptome-based polygenic risk score for depression.Psychiatry research · 2024Article
- In-Scanner Thoughts shape Resting-state Functional Connectivity: how participants "rest" matters.bioRxiv : the preprint server for biology · 2024Article
- Tormenting thoughts: The posterior cingulate sulcus of the default mode network regulates valence of thoughts and activity in the brain's pain network during music listening.Human brain mapping · 2022Article
- Effect of music intervention on subjective scores, heart rate variability, and prefrontal hemodynamics in patients with chronic pain.Frontiers in human neuroscience · 2022Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many individuals spend a significant amount of their time "mind-wandering". Mind-wandering often includes spontaneous, nonintentional thought, and a neural correlate of this kind of thought is the default mode network (DMN). Thoughts during mind-wandering can have positive or negative valence, but only little is known about the neural correlates of positive or negative thoughts. We used resting-state functional magnetic resonance imaging (fMRI) and music to evoke mind-wandering in n = 33 participants, with positive-sounding music eliciting thoughts with more positive valence and negative-sounding music eliciting thoughts with more negative valence. Applying purely data-driven analysis methods, we show that medial orbitofrontal cortex (mOFC, part of the ventromedial prefrontal cortex) and the posterior cingulate sulcus (likely area 23c of the posterior cingulate cortex), two sub-regions of the DMN, modulate the valence of thought-contents during mind-wandering. In addition, across two independent experiments, we observed that the posterior cingulate sulcus, a region involved in pain, shows valence-specific functional connectivity with core regions of the brain's putative pain network. Our results suggest that two DMN regions (mOFC and posterior cingulate sulcus) support the formation of negative spontaneous, nonintentional thoughts, and that the interplay between these structures with regions of the putative pain network forms a neural mechanism by which thoughts can become painful.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.