ArticleJournal of pharmacokinetics and pharmacodynamics2022
Semi-empirical anticoagulation model (SAM): INR monitoring during Warfarin therapy.
Article in Journal of pharmacokinetics and pharmacodynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Assessment of community pharmacists' knowledge, attitudes, awareness, and practice-related responses regarding oral anticoagulants in the Northern West Bank, Palestine: a cross-sectional study.Journal of pharmaceutical health care and sciences · 2026Article
- An Unlikely Culprit of Hospital-Acquired Warfarin Resistance: A Case Report and Review of Literature.International medical case reports journal · 2026Article
- Multi-Target Anticoagulant Regulation by Peptides from Medicinal Leeches: A Unique Natural Strategy against Thrombosis.Pharmaceutical research · 2026Review
- Effects of sodium ferulate for injection on anticoagulation of warfarin in rats in vivo.BMC complementary medicine and therapies · 2024Article
- Deriving mechanism-based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin.CPT: pharmacometrics & systems pharmacology · 2023Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
The International Normalized Ratio (INR) monitoring is an essential component to manage thrombotic disease therapy. This study presents a semi-empirical model of INR as a function of time and assigned therapy (Warfarin, k-vitamin). With respect to other methodologies, this model is able to describe the INR using a limited number of parameters and is able to describe the time variation of INR described in the literature. The presented methodology showed great accuracy in model calibration [(trueness (precision)]: 0.2% (0.1%) to 1.2% (0.3%) for coagulation factors, from 5% (9%) to 9.7% (12%) for Warfarin-related parameters and 38% (40%) for K-vitamin-related parameters. The latter value was considered acceptable given the assumptions made in the model. It has two other important results: the first is that it was able to correctly estimate INR with respect to daily therapy doses taken from the literature. The second is that it introduces a single numeric semi-empirical parameter that is able to correlate INR/dose response to physiological and environmental condition of patients.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.