Evidence map›Paper›PMID 34652580›Full record

ArticleCellular and molecular neurobiology2022

Introduction to the Special Issue "The Brain-Gut Axis".

Yvette Taché, Juan M Saavedra

Abstract readEditorial
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Clinical efficacy and gastrointestinal hormonal effect ofAmerican journal of translational research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yvette TachéDavid Geffen School of Medicine at UCLA, 11301 Wilshire Boulevard, CURE Building 115, Room 117, Los Angeles, CA, 90073, USA.ORCID http://orcid.org/0000-0002-1044-5279
Juan M SaavedraDepartment of Pharmacology and Physiology, Georgetown University Medical Center, SE402 Med/Dent, 3900, Reservoir Road, Washington, DC, 20057, USA. juan.saavedra@georgetown.edu.ORCID http://orcid.org/0000-0002-7238-9647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in variety of neurological disorders. There are intimate connections between the brain and the digestive system. Gut microbiota dysbiosis activates the intestinal immune system, enhances intestinal permeability and bacterial translocation, leading to neuroinflammation, epigenetic changes, cerebrovascular alterations, amyloid β formation and α-synuclein protein aggregates. These alterations may participate in the development of hypertension, Alzheimer, Parkinson, stroke, epilepsy and autism. Brainstem nuclei such as the nucleus tractus solitarius (NTS) and the dorsal motor nucleus of the vagus (DMV) regulate gastric motor function by way of bidirectional inputs through the vagus nerve.

Indexed as

Brain-Gut AxisGastrointestinal MicrobiomeAmyloid beta-PeptidesBrainDysbiosisHumansSolitary NucleusAmyloid beta-PeptidesBrain inflammationGut dysbiosisNeurodegenerative disordersStressStroke

Identifiers

PMID34652580
PMCPMC11441172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.